Results 261 to 270 of about 113,399 (298)
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Molecular Membrane Biology, 1999
Homotypic fusion between early endosomes can be reconstituted in vitro. By using wortmannin and LY294002, inhibitors of phosphatidylinositol (Pl) 3-kinase, a requirement for this activity has been established in order for fusion to proceed efficiently.
Mills, I G, Jones, A T, Clague, M J
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Homotypic fusion between early endosomes can be reconstituted in vitro. By using wortmannin and LY294002, inhibitors of phosphatidylinositol (Pl) 3-kinase, a requirement for this activity has been established in order for fusion to proceed efficiently.
Mills, I G, Jones, A T, Clague, M J
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Biochemical Society Transactions, 2010
The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio +2 more
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The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio +2 more
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Endosomal Signaling and Oncogenesis
2014The endosomal system provides a route whereby nutrients, viruses, and receptors are internalized. During the course of endocytosis, activated receptors can accumulate within endosomal structures and certain signal-transducing molecules can be recruited to endosomal membranes.
Engedal, Nikolai, Mills, Ian G
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2014
The transforming growth factor beta (TGFβ) signaling pathway is important for normal cell homeostasis and has critical roles in apoptosis, cell-cycle arrest, and cellular differentiation (reviewed in Massague, 2008). In the classical TGFβ pathway, the endosomal trafficking of receptors has a direct outcome on signal transduction-receptors internalized ...
Sarah, McLean, Gianni M, Di Guglielmo
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The transforming growth factor beta (TGFβ) signaling pathway is important for normal cell homeostasis and has critical roles in apoptosis, cell-cycle arrest, and cellular differentiation (reviewed in Massague, 2008). In the classical TGFβ pathway, the endosomal trafficking of receptors has a direct outcome on signal transduction-receptors internalized ...
Sarah, McLean, Gianni M, Di Guglielmo
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2021
During the development of the nervous system, neurons respond to diffusible cues secreted by target cells. Because such target-derived factors regulate development, maturation, and maintenance of axons as well as somatodendritic compartments, signals initiated at distal axons must be retrogradely transmitted toward cell bodies. Neurotrophins, including
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During the development of the nervous system, neurons respond to diffusible cues secreted by target cells. Because such target-derived factors regulate development, maturation, and maintenance of axons as well as somatodendritic compartments, signals initiated at distal axons must be retrogradely transmitted toward cell bodies. Neurotrophins, including
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Multivesicular Bodies and Multivesicular Endosomes: The "Ins and Outs" of Endosomal Traffic
Science's STKE, 2002Multivesicular endosomes (MVEs) are complex intracellular organelles that function in endocytosis. A major function of the endocytic pathway is to sort internalized macromolecules and membrane proteins. Appropriately sorted proteins, such as epidermal growth factor (EGF) receptor (EGFR), are incorporated into MVEs before transport to the lysosomal ...
Philip D, Stahl, M Alejandro, Barbieri
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Annexins and Endosomal Signaling
2014Cell signaling and endocytosis are intimately linked in eukaryotic cells. Signaling receptors at the cell surface enter the endocytic pathway and continue to activate downstream effectors in endosomal compartments. This spatiotemporal regulation of signal transduction provides opportunity for signal diversity and a cell-specific machinery of ...
Francesc, Tebar +7 more
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Acidification of Lysosomes and Endosomes
1996Lysosomes, endosomes, and a variety of other intracellular organelles are acidified by a family of unique proton pumps, termed the vacuolar H(+)-ATPases, that are evolutionarily related to bacterial membrane proton pumps and the F1-F0 H(+)-ATPases that catalyze ATP synthesis in mitochondria and chloroplasts.
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Nature Reviews Immunology, 2019
Two papers by Gregory Barton and colleagues identify distinct UNC93B1-dependent mechanisms for regulation of the endosomal nucleic acid-sensing TLRs, TLR7 and TLR9.
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Two papers by Gregory Barton and colleagues identify distinct UNC93B1-dependent mechanisms for regulation of the endosomal nucleic acid-sensing TLRs, TLR7 and TLR9.
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2003
The endocytic pathway receives cargo from the cell surface via endocytosis, biosynthetic cargo from the late Golgi complex, and various molecules from the cytoplasm via autophagy. This review focuses on the dynamics of the endocytic pathway in relationship to these processes and covers new information about the sorting events and molecular complexes ...
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The endocytic pathway receives cargo from the cell surface via endocytosis, biosynthetic cargo from the late Golgi complex, and various molecules from the cytoplasm via autophagy. This review focuses on the dynamics of the endocytic pathway in relationship to these processes and covers new information about the sorting events and molecular complexes ...
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