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Endosomal and non-endosomal functions of ESCRT proteins
Trends in Cell Biology, 2006The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that ...
Thomas, Slagsvold +3 more
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Int. Journal of Clinical Pharmacology and Therapeutics, 2009
Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network.
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Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network.
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The Endosomal Network: Mediators and Regulators of Endosome Maturation
2018Endocytosis is a means for the cell to sample its environment for nutrients and regulate plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is recycled back to the cell surface, select material is sent to the lysosome for degradation.
Podinovskaia, Maria, Spang, Anne
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Endosomal system of Paramecium: coated pits to early endosomes
Journal of Cell Science, 1992ABSTRACT A detailed morphological and tracer study of endocytosis via coated pits in Paramecium multimicronucleatum was undertaken to compare endocytic processes in a free-living protozoon with similar processes in higher organisms. Permanent pits at the cell surface enlarge, become coated and give rise to coated vesicles (188±41 nm in ...
R D, Allen, C C, Schroeder, A K, Fok
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Late endosomes derive from early endosomes by maturation
Cell, 1991Endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endosomes following uptake. Late endosomes are the major site for entry of newly synthesized lysosomal hydrolases via the cation-independent mannose 6-phosphate receptor into the degradative pathway. No consensus exists as to the mechanism of transport from early to
Stoorvogel, W +4 more
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Endosomal trafficking in schizophrenia
Current Opinion in Neurobiology, 2022Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a combination of common genetic variation, rare loss of function variation, and copy number variation. Functional genomic evidence has been used to identify candidate genes affected by this variation, which revealed biological pathways that may be disrupted in ...
Melissa Plooster +2 more
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Plant signaling endosomes and endosome trafficking
Russian Journal of Plant Physiology, 2010A discovery of a possibility for signal transduction from endosomes differing quantitatively and qualitatively from signaling from the plasma membrane became a reliably proved fact for animal and yeast receptors but was unaddressed by plant researches for a long time.
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Endosomes, receptors, and viruses
Science, 2022Mechanisms of infection are deciphered at the host-pathogen ...
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Traffic, 2008
Plant endosomes are highly dynamic organelles that are involved in the constitutive recycling of plasma membrane cargo and the trafficking of polarized plasma membrane proteins such as auxin carriers. In addition, recent studies have shown that surface receptors such as the plant defense‐related FLS2 receptor and the brassinosteroid receptor BRI1 ...
Marisa S, Otegui, Christoph, Spitzer
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Plant endosomes are highly dynamic organelles that are involved in the constitutive recycling of plasma membrane cargo and the trafficking of polarized plasma membrane proteins such as auxin carriers. In addition, recent studies have shown that surface receptors such as the plant defense‐related FLS2 receptor and the brassinosteroid receptor BRI1 ...
Marisa S, Otegui, Christoph, Spitzer
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The biogenesis of multivesicular endosomes
Nature Reviews Molecular Cell Biology, 2004Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the
Gruenberg, Jean, Stenmark, Harald
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