Results 41 to 50 of about 703 (170)
The FEBS Journal, Volume 293, Issue 1, Page 42-70, January 2026.This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leanna Leverton +4 more
wiley +1 more source
Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma
Cancer Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background Uveal melanoma (UM) is the prevailing malignant tumor that develops within the eye in adults, and it has a bleak outlook because of the few treatment choices available and the high likelihood of returning after treatment. Currently, surgical intervention, radiation therapy, and a combination of both modalities are available ...
Alireza Azani +13 more
wiley +1 more source
Genetic studies of collagen types XV and XVIII : Type XV collagen deficiency in mice results in skeletal myopathy and cardiovascular defects, while the homologous endostatin precursor type XVIII collagen is needed for normal development of the eye [PDF]
, 2001 Overlapping genomic clones coding for the α1 chain of mouse type XV collagen (Col15a1) were isolated. The gene was found to be 110 kb in length and to contain 40 exons.
Eklund, Lauri
core
Unraveling the mysteries of endostatin [PDF]
IUBMB Life, 2009 AbstractEndostatin, a 20‐kDa C‐terminal proteolytic fragment of collagen XVIII, is a specific endogenous angiogenesis inhibitor discovered more than a decade. The structure, stability, and mechanism of actions of endostatin have been extensively investigated during the past 12 years, among which controversial reports remain unclarified.
Yan, Fu +4 more
openaire +2 more sources
JOR SPINE, Volume 8, Issue 4, December 2025.Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley +1 more source
Type XV collagen : Complete structures of the human COL15A1 and mouse Col15a1 genes, location of type XV collagen protein in mature and developing mouse tissues, and generation of mice expressing truncated type XV collagen [PDF]
, 2001 This study was initiated to elucidate the complete genomic structures of type XV collagen in man and mouse and the functional properties of their promoters, as well as to obtain knowledge of the biological role of type XV collagen during development and ...
Muona, Anu
core
Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy [PDF]
Clinical Cancer Research, 2008 Abstract Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino acids gives rise to a molecule that is devoid of zinc, resulting in no antitumor ...
Tong-Young, Lee +8 more
openaire +2 more sources
Respirology Case Reports, Volume 13, Issue 12, December 2025.In this report, we present a case of a 30‐year‐old female who initially presented with recurrent hemoptysis and multiple pulmonary nodules with exudative changes in the lung, pathologically resembling granulomatous lesions and eventually confirmed as primary cardiac angiosarcoma with pulmonary metastasis.
Weiqi Mao +7 more
wiley +1 more source
CD8+ T Cells Negatively Modulate Ischemia‐Induced Angiogenesis in Mice
The FASEB Journal, Volume 39, Issue 22, 30 November 2025.Graphical illustration of the mechanism of CD8+ T‐cells/IFN‐γ axis‐mediated angiogenesis in response to ischemic stress. CD8+ T‐cell functions as an important mediator of ischemia‐induced angiogenesis via the modulation of inflammation, oxidative stress, proteolysis, and endothelial proliferation that might be mediated by the IFN‐γ/NLRp3‐caspase‐1 and ...
Xianji Piao +13 more
wiley +1 more source
Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin
Drug Development Research, Volume 86, Issue 7, November 2025.ABSTRACT Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new synthetic vasoinhibin analog, has therapeutic potential for targeting angiogenesis in oncology and ...
Miguel A. García‐González +13 more
wiley +1 more source