Results 21 to 30 of about 600 (104)
MedComm, Volume 7, Issue 9, September 2026.Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi +17 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1420-1435, July 2026.Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde +9 more
wiley +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, Volume 293, Issue 13, Page 3991-4013, July 2026.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, Volume 293, Issue 13, Page 4043-4063, July 2026.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
, 2002 Endostatins are inhibitors of endothelial cell migration and angiogenesis and have been shown to reduce tumor growth in animal models. They are derived from the nontriplehelical C- terminal NC1 domains of collagens XV and XVIII, which are released ...
Hohenester, E., Timpl, R., Sasaki, T.
core
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source