Results 51 to 60 of about 603,202 (260)

Persisting Endothelial Cell Activation and Hypercoagulability after COVID-19 Recovery—The Prospective Observational ROADMAP-Post COVID-19 Study

Hemato, 2022
Background. Hypercoagulable state and endothelial cell activation are common alterations in patients with COVID-19. Nevertheless, the hypothesis of persistent hypercoagulability and endothelial cell activation following recovery from COVID-19 remains an ...
Grigorios T. Gerotziafas, Patrick Van Dreden, Theodoros N. Sergentanis, Marianna Politou, Aurélie Rousseau, Matthieu Grusse, Michèle Sabbah, Ismail Elalamy, Vasiliki Pappa, Tina Skourti, Tina Bagratuni, Ioannis Ntanasis-Stathopoulos, Eleni Korompoki, Stavroula Labropoulou, Meletios A. Dimopoulos, Evangelos Terpos   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights

Biomedicines
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, Sebastian Michel, Reinhard Ellgass, Katja Gieseke, Stig Steen, Audrius Paskevicius, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Martin B. Müller, Matthias Längin   +23 more
doaj   +1 more source

Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells

Frontiers in Immunology, 2019
In sepsis, dysregulated immune responses to infections cause damage to the host. Previous studies have attempted to capture pathogen-induced leukocyte responses.
Kieu T. T. Le, Xiaojing Chu, Martin Jaeger, Josée A. Plantinga, Vasiliki Matzaraki, Sebo Withoff, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Cisca Wijmenga, Yang Li, Jill Moser, Jill Moser, Vinod Kumar, Vinod Kumar   +14 more
doaj   +1 more source

Connexin40 controls endothelial activation by dampening NFκB activation

Oncotarget, 2017
Connexins are proteins forming gap junction channels for intercellular communication. Connexin40 (Cx40) is highly expressed by endothelial cells (ECs) of healthy arteries but this expression is lost in ECs overlying atherosclerotic plaques. Low/oscillatory shear stress observed in bends and bifurcations of arteries is atherogenic partly through ...
Denis, Jean-François, Scheckenbach, Ludwig, Pfenniger, Anna, Meens, Merlijn, Krams, Rob, Miquerol, Lucile, Taffet, Steven, Chanson, Marc, Delmar, Mario, Kwak, Brenda   +9 more
openaire   +6 more sources

Characterization of the lipolytic activity of endothelial lipase [PDF]

Journal of Lipid Research, 2002
Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity. Using radiolabeled lipid substrates, we characterized the lipolytic activity of this enzyme in comparison to lipoprotein lipase (LPL) and hepatic lipase (HL) using conditioned medium from cells infected with recombinant ...
Mary G. McCoy, Gwo-Shing Sun, Dawn Marchadier, Cyrille Maugeais, Jane M. Glick, Daniel J. Rader   +5 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis

Mediators of Inflammation, 2013
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA.
Patrick H. Dessein, Ahmed Solomon, Angela J. Woodiwiss, Gavin R. Norton, Linda Tsang, Miguel A. Gonzalez-Gay   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source