Results 31 to 40 of about 603,202 (260)

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

eLife, 2021
Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax infection can lead to poor clinical outcomes, despite low peripheral parasitaemia, remains a matter of intense debate. Estimation of total P.
João L Silva-Filho, João CK Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder I Nakaya, Erich V De Paula, Stefanie CP Lopes, Marcus VG Lacerda, Matthias Marti, Fabio TM Costa   +11 more
doaj   +1 more source

The vascular endothelium as decision maker in lung injury

Frontiers in Cell and Developmental Biology
The vascular endothelium is the largest organ in the human body, capable of performing a wide range of cellular signaling and synthetic functions. It is also subjected to considerable mechanical stress due to the shear forces generated by blood flow ...
Diana Klein
doaj   +1 more source

Endothelial Dysfunction in Obese Children [PDF]

National Journal of Laboratory Medicine, 2015
The magnitude of lifetime risk of cardiovascular disease (CVD) has radically increased along with the high prevalence of obesity in children.
Namrata Chhabra, Sahiba Kukreja , Sahil Chhabra, Sarah Chhabra, Kavish Ramessur   +4 more
doaj   +1 more source

Increased expression of cell adhesion molecules in myofasciitis

Frontiers in Neurology, 2023
BackgroundMyofasciitis is a heterogeneous group of diseases pathologically characterized by inflammatory cell infiltration into the fascia. Endothelial activation plays a critical role in the pathogenesis of the inflammatory response.
Xue Ma, Xue Ma, Huajie Gao, Li Xu, Zhuajin Bi, Suqiong Ji, Bitao Bu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells

Metabolites, 2021
Endothelial ABCA1 expression protects against atherosclerosis and this atheroprotective effect is partially attributed to enhancing apoAI-mediated cholesterol efflux.
Kun Huang, Hanjoong Jo, Jing Echesabal-Chen, Alexis Stamatikos   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multimodal measurement of glycocalyx degradation during coronary artery bypass grafting

Frontiers in Medicine, 2022
BackgroundGlycocalyx shedding and subsequent endothelial dysfunction occur in many conditions, such as in sepsis, in critical illness, and during major surgery such as in coronary artery bypass grafting (CABG) where it has been shown to associate with ...
Martine E. Bol, Martine E. Bol, J. B. Huckriede, K. G. H. van de Pas, T. Delhaas, R. Lorusso, R. Lorusso, G. A. F. Nicolaes, J. E. M. Sels, J. E. M. Sels, J. E. M. Sels, M. C. G. van de Poll, M. C. G. van de Poll, M. C. G. van de Poll   +13 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Circulating Vascular Cell Adhesion Molecule‐1 and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis (MESA)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Serum levels of vascular cell adhesion molecule‐1 (VCAM‐1) are reflective of endothelial activation. Although VCAM‐1 has been implicated in the pathogenesis of heart failure with preserved ejection fraction (HFpEF), the prospective association
Ravi B. Patel, Laura A. Colangelo, Suzette J. Bielinski, Nicholas B. Larson, Jingzhong Ding, Norrina B. Allen, Erin D. Michos, Sanjiv J. Shah, Donald M. Lloyd‐Jones   +8 more
doaj   +1 more source