Results 11 to 20 of about 603,202 (260)

Taming endothelial activation with a microRNA [PDF]

Journal of Clinical Investigation, 2012
Inflammation plays an essential role in vascular pathologies, including those associated with sepsis and atherosclerosis. Identifying negative regulators of inflammatory signaling pathways may provide novel therapeutic targets for these diseases. In this issue of the JCI, Sun et al.
Jason E, Fish, Myron I, Cybulsky
openaire   +2 more sources

Endothelial activation impairs the function of small extracellular vesicles

Frontiers in Pharmacology, 2023
Small extracellular vesicles are nanosized vesicles (30–200 nm) that can ferry proteins, nucleic acids, and lipids between cells and therefore, have significant potential as biomarkers, drug delivery tools or therapeutic agents.
Nicolas Herrera-Zelada, Úrsula Zúñiga-Cuevas, Andrés Ramírez-Reyes, Ignacio Norambuena-Soto, Leslye Venegas-Zamora, Mayarling F. Troncoso, Alejandra Hernández, Gina Sánchez, Zully Pedrozo, Zully Pedrozo, Sergio Lavandero, Sergio Lavandero, Jaime A. Riquelme, Jaime A. Riquelme, Jaime A. Riquelme   +14 more
doaj   +1 more source

Intestinal Ischemia as a Complication of COVID-19

Dubai Medical Journal, 2021
Background: Extrapulmonary complications of COVID-19 including acute mesenteric ischemia are being increasingly reported and are a reason of poorer clinical outcome and increased inpatient mortality rate.
Lamis K. Abufool, Labib S. Al-Ozaibi
doaj   +1 more source

Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial Remodeling

Viruses, 2023
Neurological effects of COVID-19 and long-COVID-19, as well as neuroinvasion by SARS-CoV-2, still pose several questions and are of both clinical and scientific relevance.
Carolline Soares Motta, Silvia Torices, Barbara Gomes da Rosa, Anne Caroline Marcos, Liandra Alvarez-Rosa, Michele Siqueira, Thaidy Moreno-Rodriguez, Aline da Rocha Matos, Braulia Costa Caetano, Jessica Santa Cruz de Carvalho Martins, Luis Gladulich, Erick Loiola, Olivia R. M. Bagshaw, Jeffrey A. Stuart, Marilda M. Siqueira, Joice Stipursky, Michal Toborek, Daniel Adesse   +17 more
doaj   +1 more source

C-Peptide as a Therapy for Type 1 Diabetes Mellitus

Biomedicines, 2021
Diabetes mellitus (DM) is a complex metabolic disease affecting one-third of the United States population. It is characterized by hyperglycemia, where the hormone insulin is either not produced sufficiently or where there is a resistance to insulin ...
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour   +6 more
doaj   +1 more source

Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

Food & Nutrition Research, 2016
Background: Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of the action of TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions
Suhaila Muid, Gabriele R. Anisah Froemming, Thuhairah Rahman, A. Manaf Ali, Hapizah M. Nawawi   +4 more
doaj   +1 more source

Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review

Biomedicines, 2022
The monolayer of cells that line both the heart and the entire vasculature is the endothelial cell (EC). These cells respond to external and internal signals, producing a wide array of primary or secondary messengers involved in coagulation, vascular ...
Jose A. Adams, Arkady Uryash, Jose R. Lopez   +2 more
doaj   +1 more source

Polymorphysm of UCP2 and H2O2 concentration to the CEC Level Variations As Predictors of Endothelial Activation In Stroke

Majalah Kardiologi Indonesia, 2016
Research Background. Stroke as brain vascular disorder that can be ruptured vascular commonly referred to as a bleeding stroke or ischemic stroke may be due to cerebral arterial thrombosis as a final impact the progression of atherosclerosis, especially ...
M.Nur FAFA, Djanggan Sargowo, Achdiat Agoes, Wiwit Nurwidyaningtyas   +3 more
doaj   +1 more source

Linking endothelial dysfunction with endothelial cell activation [PDF]

Journal of Clinical Investigation, 2013
The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration.
openaire   +2 more sources

The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

Frontiers in Pharmacology, 2018
Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis.
Dania Fischer, Christopher Seifen, Patrick Baer, Michaela Jung, Christina Mertens, Bertram Scheller, Kai Zacharowski, Rainer Hofmann, Thorsten J. Maier, Thorsten J. Maier, Anja Urbschat, Anja Urbschat   +11 more
doaj   +1 more source