Results 21 to 30 of about 603,202 (260)

HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk [PDF]

Circulation Research, 2020
Rationale: People living with HIV on effective antiretroviral therapy are at increased risk of cardiovascular complications, possibly due to off-target drug effects. Some studies have associated antiretroviral therapy with increased risk of myocardial infarction and endothelial dysfunction, but a link between endothelial ...
Akif A. Khawaja, Kirk A. Taylor, Andrew O. Lovell, Mark Nelson, Brian Gazzard, Marta Boffito, Michael Emerson   +6 more
openaire   +3 more sources

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

Frontiers in Immunology, 2018
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features.
Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina   +47 more
doaj   +1 more source

Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients

Vaccines, 2020
Systemic inflammation, endothelial dysfunction and coagulopathy are of high clinical relevance in the management of people living with HIV (PLWH), and even more in patients coinfected with hepatitis C virus (HCV).
Beatriz Álvarez, Clara Restrepo, Marcial García, María A. Navarrete-Muñoz, María A. Jiménez-Sousa, Laura Prieto, Alfonso Cabello, Sara Nistal, Salvador Resino, Miguel Górgolas, Norma Rallón, José M. Benito   +11 more
doaj   +1 more source

Statins in Endothelial Signaling and Activation [PDF]

Antioxidants & Redox Signaling, 2009
The beneficial effects of statins, the most widely prescribed class of drugs in the world, are now recognized to extend well beyond their lipid-lowering properties. Through a combination of both distinct and interdependent effects on endothelial cell (EC) Rho GTPase regulation, NAPDH oxidase activity, NO bioavailability, and ...
openaire   +2 more sources

Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome

Cells, 2020
Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia.
Ula Štok, Elizabeta Blokar, Metka Lenassi, Marija Holcar, Mojca Frank-Bertoncelj, Andreja Erman, Nataša Resnik, Snežna Sodin-Šemrl, Saša Čučnik, Katja Perdan Pirkmajer, Aleš Ambrožič, Polona Žigon   +11 more
doaj   +1 more source

Vascular Signaling in Allogenic Solid Organ Transplantation – The Role of Endothelial Cells

Frontiers in Physiology, 2020
Graft rejection remains the major obstacle after vascularized solid organ transplantation. Endothelial cells, which form the interface between the transplanted graft and the host’s immunity, are the first target for host immune cells.
Laura Kummer, Marcin Zaradzki, Vijith Vijayan, Rawa Arif, Markus A. Weigand, Stephan Immenschuh, Andreas H. Wagner, Jan Larmann   +7 more
doaj   +1 more source

Reciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

Journal of Nanobiotechnology, 2022
Highlights 1. CuONPs exposure activates NRF2 signaling in vascular endothelial cells and mouse thoracic aorta. 2. KEAP1 is dispensable for NRF2 activation in CuONPs-treated vascular endothelial cells. 3.
Na Li, Hang Du, Lejiao Mao, Ge Xu, Mengling Zhang, Yinzhen Fan, Xiaomei Dong, Lijun Zheng, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Zhen Zou, Jun Zhang   +13 more
doaj   +1 more source

A systematic review of diagnostic, prognostic, and risk blood and urine biomarkers of transplant-associated thrombotic microangiopathy

Frontiers in Immunology, 2023
Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized complication of allogeneic and autologous hematopoietic cellular therapy (HCT), associated with significant morbidity and mortality.
Michelle L. Schoettler, Michelle L. Schoettler, Harshil Bhatt, Sumithira Vasu   +3 more
doaj   +1 more source

TRPV4 channel activation induces the transition of venous and arterial endothelial cells toward a pro‐inflammatory phenotype

Physiological Reports, 2021
The Transient Receptor Potential Vanilloid 4 (TRPV4) of endothelial cells contributes to many important functions including the regulation of Ca2+ homeostasis, cell volume, endothelial barrier permeability, and smooth muscle tone.
Kathia Beddek, Florent Raffin, Delphine Borgel, François Saller, Diane Riccobono, Régis Bobe, François‐Xavier Boittin   +6 more
doaj   +1 more source

Endothelial activation and stress index for prediction of mortality in asthma [PDF]

Frontiers in Medicine
Jiang Wenyan
exaly   +2 more sources