Results 21 to 30 of about 931,139 (309)

TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]

, 2020
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core   +1 more source

Sustained apnea induces endothelial activation [PDF]

Clinical Cardiology, 2017
BackgroundApnea diving has gained worldwide popularity, even though the pathophysiological consequences of this challenging sport on the human body are poorly investigated and understood. This study aims to assess the influence of sustained apnea in healthy volunteers on circulating microparticles (MPs) and microRNAs (miRs), which are established ...
Lars Eichhorn, Ramona Dolscheid‐Pommerich, Felix Erdfelder, Muhammad Ajmal Ayub, Theresa Schmitz, Nikos Werner, Felix Jansen   +6 more
openaire   +2 more sources

Polymorphysm of UCP2 and H2O2 concentration to the CEC Level Variations As Predictors of Endothelial Activation In Stroke

Majalah Kardiologi Indonesia, 2016
Research Background. Stroke as brain vascular disorder that can be ruptured vascular commonly referred to as a bleeding stroke or ischemic stroke may be due to cerebral arterial thrombosis as a final impact the progression of atherosclerosis, especially ...
M.Nur FAFA, Djanggan Sargowo, Achdiat Agoes, Wiwit Nurwidyaningtyas   +3 more
doaj   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Gloe, Torsten, Hennig, Theres, Kirsch, Julian, Mogensen, Christina, Pohl, Ulrich   +4 more
core   +1 more source

The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

Frontiers in Pharmacology, 2018
Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis.
Dania Fischer, Christopher Seifen, Patrick Baer, Michaela Jung, Christina Mertens, Bertram Scheller, Kai Zacharowski, Rainer Hofmann, Thorsten J. Maier, Thorsten J. Maier, Anja Urbschat, Anja Urbschat   +11 more
doaj   +1 more source

Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase [PDF]

, 2008
<b>Objective</b>— Proatherosclerotic adhesion of leukocytes to the endothelium is attenuated by NO. As AMP-activated protein kinase (AMPK) regulates endothelial NO synthesis, we investigated the modulation of adhesion to cultured human aortic
Ewart, M-A., Kohlhaas, C.F., Salt, I.P.
core   +1 more source

Linking endothelial dysfunction with endothelial cell activation [PDF]

Journal of Clinical Investigation, 2013
The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration.
openaire   +2 more sources

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

Frontiers in Immunology, 2018
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features.
Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina   +47 more
doaj   +1 more source

Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients

Vaccines, 2020
Systemic inflammation, endothelial dysfunction and coagulopathy are of high clinical relevance in the management of people living with HIV (PLWH), and even more in patients coinfected with hepatitis C virus (HCV).
Beatriz Álvarez, Clara Restrepo, Marcial García, María A. Navarrete-Muñoz, María A. Jiménez-Sousa, Laura Prieto, Alfonso Cabello, Sara Nistal, Salvador Resino, Miguel Górgolas, Norma Rallón, José M. Benito   +11 more
doaj   +1 more source

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source