Results 41 to 50 of about 6,939,193 (345)

Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

Nature Communications, 2020
The presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system.
Tomoyuki Mutoh, T. Shirai, T. Ishii, Y. Shirota, F. Fujishima, Fumiaki Takahashi, Y. Kakuta, Y. Kanazawa, A. Masamune, Y. Saiki, H. Harigae, H. Fujii   +11 more
semanticscholar   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P., Bourdoulous, S., Pierre-Olivier Couraud, John Greenwood, Leveque, M., Greenwood, J., Mathilde Leveque, Rampon, C., Couraud, P.-O., Jean-Pierre Couty, Christine Rampon, Marie-Pierre Laran-Chich, Couty, J.-P., Sandrine Bourdoulous   +13 more
core   +1 more source

Linking endothelial dysfunction with endothelial cell activation [PDF]

Journal of Clinical Investigation, 2013
The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration.
openaire   +2 more sources

Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019

Journal of International Medical Research, 2020
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern. Increased morbidity and mortality is associated with older age, male gender, cardiovascular disease, diabetes ...
M. Hayden
semanticscholar   +1 more source

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase [PDF]

, 2009
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E., Ingrid Fleming, Annemarieke E. Loot, Fißlthaler, Beate, Fleming, Ingrid, Judith G. Schreiber, Beate Fisslthaler, Schreiber, Judith G.   +7 more
core   +1 more source

HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk [PDF]

Circulation Research, 2020
Rationale: People living with HIV on effective antiretroviral therapy are at increased risk of cardiovascular complications, possibly due to off-target drug effects. Some studies have associated antiretroviral therapy with increased risk of myocardial infarction and endothelial dysfunction, but a link between endothelial ...
Akif A. Khawaja, Kirk A. Taylor, Andrew O. Lovell, Mark Nelson, Brian Gazzard, Marta Boffito, Michael Emerson   +6 more
openaire   +3 more sources

The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

Frontiers in Pharmacology, 2018
Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis.
Dania Fischer, Christopher Seifen, Patrick Baer, Michaela Jung, Christina Mertens, Bertram Scheller, Kai Zacharowski, Rainer Hofmann, Thorsten J. Maier, Thorsten J. Maier, Anja Urbschat, Anja Urbschat   +11 more
doaj   +1 more source

Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria

Critical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: Evaluate the relationship between endothelial activation, malaria complications, and long-term cognitive outcomes in severe malaria survivors.
Benson J. Ouma, J. Ssenkusu, E. Shabani, D. Datta, R. Opoka, R. Idro, P. Bangirana, Gregory S. Park, M. Joloba, K. Kain, Chandy C. John, A. Conroy   +11 more
semanticscholar   +1 more source

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

Frontiers in Immunology, 2018
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features.
Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina   +47 more
doaj   +1 more source

Statins in Endothelial Signaling and Activation [PDF]

Antioxidants & Redox Signaling, 2009
The beneficial effects of statins, the most widely prescribed class of drugs in the world, are now recognized to extend well beyond their lipid-lowering properties. Through a combination of both distinct and interdependent effects on endothelial cell (EC) Rho GTPase regulation, NAPDH oxidase activity, NO bioavailability, and ...
openaire   +2 more sources