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Biomarkers of endothelial activation and dysfunction in cardiovascular diseases [PDF]
Reviews in Cardiovascular Medicine, 2022 Endothelial activation and dysfunction is an important contributor to atherosclerosis, cardiovascular diseases and cardiorenal syndrome. Endothelial dysfunction is also linked with metabolic syndrome and type II diabetes.
Jun Zhang
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Endothelial Integrin‐Linked Kinase (ILK) Deficiency Promotes Endothelial Activation and Cardiovascular Dysfunction via Receptor Interacting Protein Kinase‐1 (RIPK1) Enriched‐Extracellular Vesicle Signalling [PDF]
Journal of Extracellular VesiclesIntegrin‐linked kinase (ILK) maintains endothelial homeostasis by supporting endothelial nitric oxide synthase activity and restraining vascular inflammation. Although endothelial ILK loss is linked to vascular and cardiac disease, the mechanisms driving
Alberto Cook‐Calvete +9 more
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Proteomic Analysis of Endothelial Activation Induced by Adult Angiostrongylus vasorum Homogenate: Insights into Vascular Remodeling and Hemostatic Imbalance [PDF]
AnimalsThe interaction between Angiostrongylus vasorum and the vascular endothelium of the host plays a key role in the pathogenesis of canine angiostrongylosis. The adult stage of A.
Manuel Collado-Cuadrado +9 more
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Endothelial cell activation [PDF]
Kidney International, 1998 The endothelium is now recognised as not simply being an inert lining to blood vessels, as thought in the 1960s, but a highly specialised, metabolically active interface between blood and the underlying tissues—maintaining vascular tone, thromboresistance, and a selective permeability to cells and proteins.
B J, Hunt, K M, Jurd
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Biomedicines, 2022 Cysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction ...
Marta Reina-Couto +14 more
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Frontiers in Cardiovascular Medicine, 2023 BackgroundThe deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (
Minh T. H. Nguyen +25 more
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The impact of biological age of red blood cell on in vitro endothelial activation markers
Frontiers in Physiology, 2023 Introduction: Blood donor characteristics influence red blood cell transfusion outcomes. As donor sex affects the distribution of young to old RBCs in the circulation, we hypothesized that the amount of circulating young RBCs in the blood product are ...
Abdulrahman Alshalani +8 more
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Aldosterone activates endothelial exocytosis [PDF]
Proceedings of the National Academy of Sciences, 2009 Although elevated levels of aldosterone are associated with vascular inflammation, the proinflammatory pathways of aldosterone are not completely defined. We now show that aldosterone triggers endothelial cell exocytosis, the first step in leukocyte trafficking.
Youngtae, Jeong +6 more
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Treatment Reducing Endothelial Activation Protects against Experimental Cerebral Malaria
Pathogens, 2022 Cerebral malaria (CM) is the most severe neurological complication of malaria caused by Plasmodium falciparum infection. The available antimalarial drugs are effective at clearing the parasite, but the mortality rate remains as high as 20% of CM cases ...
Sabrina Mota +5 more
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Biomedicines, 2021 Background. Emerging evidences suggest that in severe COVID-19, multi-organ failure is associated with a hyperinflammatory state (the so-called “cytokine storm”) in combination with the development of a prothrombotic state.
Bianca Maria Rotoli +4 more
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