Results 1 to 10 of about 6,939,193 (345)

Biomarkers of endothelial activation and dysfunction in cardiovascular diseases [PDF]

Reviews in Cardiovascular Medicine, 2022
Endothelial activation and dysfunction is an important contributor to atherosclerosis, cardiovascular diseases and cardiorenal syndrome. Endothelial dysfunction is also linked with metabolic syndrome and type II diabetes.
Jun Zhang
doaj   +4 more sources

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6

Circulation Research, 2018
Rationale: Microvascular inflammation and endothelial dysfunction secondary to unchecked activation of endothelium play a critical role in the pathophysiology of sepsis and organ failure.
Zhijian Qian, Kyungho Kim, You-Yang Zhao
exaly   +2 more sources

Time and Concentration Dependent Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Induced Endothelial Activation

Frontiers in Pharmacology, 2018
Background and Aim: Endothelial activation is characterized by excessive production of cytokines and chemokines as well as adhesion molecules expression which is involved in the development of atherosclerosis.
Meng Li, Betty C. A. M. van Esch, Betty C. A. M. van Esch, Paul A. J. Henricks, Johan Garssen, Johan Garssen, Gert Folkerts   +6 more
doaj   +2 more sources

Extracellular Matrix and Endothelial Activation Markers in the Bronchial and Pulmonary Arteries in COPD [PDF]

The Clinical Respiratory Journal
Background Vascular alterations contribute significantly to the chronic obstructive pulmonary disease (COPD) pathophysiology. Thirty‐nine percent of patients with COPD develop pulmonary hypertension, especially patients with the severe form of the ...
Raquel Annoni, Jôse Mára deBrito, Salvatore Battaglia, Natália deSouza Xavier Costa, Ligia Braga Lopes Couceiro, Renata Calciolari Rossi, Marisa Dolhnikoff, Pieter S. Hiemstra, Klaus F. Rabe, Peter J. Sterk, Thais Mauad   +10 more
doaj   +2 more sources

Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

European Journal of Medical Research, 2023
Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells participate in both innate and adaptive immune responses as the first cell
Min Wang, Jun Feng, Dai-Xing Zhou, Jun-Shuai Wang   +3 more
semanticscholar   +1 more source

Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock

Biomedicines, 2022
Cysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction ...
Marta Reina-Couto, Marisa Santos-Oliveira, Patrícia Pereira-Terra, Carolina Silva-Pereira, Janete Quelhas-Santos, Álvaro Duarte, Sandra Martins, Paula Serrão, Cláudia Camila Dias, Manuela Morato, João T. Guimarães, Roberto Roncon-Albuquerque, José-Artur Paiva, António Albino-Teixeira, Teresa Sousa   +14 more
doaj   +1 more source

Association Between Endothelial Activation and Stress Index and 28-Day Mortality in Septic ICU patients: a Retrospective Cohort Study

International Journal of Medical Sciences, 2023
Background: Endothelial Activation and Stress Index (EASIX) is a reliable alternative biomarker of endothelial dysfunction. Because endothelial activation is involved in sepsis pathophysiology, we aimed to investigate the association between EASIX and ...
Hong-Bo Xu, Yuan Ye, Fang Xue, Jinglan Wu, Zhi-jun Suo, Haigang Zhang   +5 more
semanticscholar   +1 more source

Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (
Minh T. H. Nguyen, Minh T. H. Nguyen, Masaki Imanishi, Shengyu Li, Khanh Chau, Priyanka Banerjee, Loka reddy Velatooru, Kyung Ae Ko, Venkata S. K. Samanthapudi, Young J. Gi, Ling-Ling Lee, Rei J. Abe, Elena McBeath, Anita Deswal, Steven H. Lin, Nicolas L. Palaskas, Robert Dantzer, Keigi Fujiwara, Mae K. Borchrdt, Estefani Berrios Turcios, Elizabeth A. Olmsted-Davis, Sivareddy Kotla, John P. Cooke, Guangyu Wang, Jun-ichi Abe, Nhat-Tu Le   +25 more
doaj   +1 more source

TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2

Signal Transduction and Targeted Therapy, 2022
Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute lung injury, however, the detailed regulatory mechanisms remain largely unknown.
Yi-Song Qian, Ziwei Wang, Hong-ru Lin, Tianhua Lei, Zhou Zhou, Weilu Huang, Xuehan Wu, Li Zuo, Jie Wu, Yu Liu, Ling-Fang Wang, Xiao-Hui Guan, Ke-Yu Deng, Mingui Fu, Hong-Bo Xin   +14 more
semanticscholar   +1 more source

Endothelial Activation and Microcirculatory Disorders in Sepsis

Frontiers in Medicine, 2022
The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover, in sepsis, endothelial cells can acquire new properties and actively participate in the host's response.
Lisa Raia, L. Zafrani
semanticscholar   +1 more source