Results 71 to 80 of about 451,622 (253)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

An endothelial-centered regulatory framework reveals context-dependent roles of MYLK in lung adenocarcinoma

Frontiers in Immunology
BackgroundLung adenocarcinoma (LUAD) is shaped by the tumor microenvironment, yet endothelial cell (EC) regulatory programs and their biological roles remain insufficiently defined.MethodsWe analyzed scRNA-seq data to map EC-associated programs and ...
Rui Li, Xiao Liu, Chen Huo, Jian-Ping Li, Yu-Xin Zhang, Shuang-Teng Liu, Yi-Qing Qu   +6 more
doaj   +1 more source

Corneal Endothelial Cell Changes Due to Combined Phacoemulsification-Posterior Chamber Intraocular Lens Implantation and Transpupillary Silicone Oil Removal

Türk Oftalmoloji Dergisi, 2014
Objectives: The aim of this study was to evaluate the effects of combined phacoemulsification-posterior chamber intraocular lens (PCIOL) implantation and removal of transpupillary silicone oil on the corneal endothelial cell layer.
Mehmet Hanifi Alp , Haluk Esgin
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Corneal endothelial changes following pars plana lensectomy

Indian Journal of Ophthalmology, 1991
The corneal endothelial status was studied in 40 eyes of patients with congenital cataract before and 3 months after surgery. Twenty eyes of patients who underwent pars plana lensectomy revealed a mean endothelial cell loss of 8% (SD + ...
Goyal J, Panda Anita, Angra S
doaj  

Association of corneal endothelial cell morphology with neurodegeneration in mild cognitive impairment and dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Corneal confocal microscopy (CCM) detects neurodegeneration in mild cognitive impairment (MCI) and dementia and identifies subjects with MCI who develop dementia.
Georgios Ponirakis, Hanadi Al Hamad, Alaa S. Al‐Waisy, Ioannis N. Petropoulos, Adnan Khan, Hoda Gad, Mani Chandran, Masharig Gadelseed, Salah Mahmoud, Ahmed Elsotouhy, Marwan Ramadan, Shafi Khan, Rustu E. Akcan, Priya V. Gawhale, Noushad Thodi, Tala Nakouzi, Moayad Homssi, Nebras Hadid, Aisha Al Obaidan, Rawan Hussein, Ahmed Own, Ashfaq Shuaib, Rayaz A. Malik   +22 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Effects of two ophthalmic viscoelastic devices on the corneal endothelium after phacoemulsification

Philippine Journal of Ophthalmology, 2008
Objective: This study compared the effects of Discovisc (DV) and Amvisc Plus (AP) on the corneal endothelium of patients after phacoemulsification cataract surgery.
Michelle Doronila Lingao, MD, Harvey Siy Uy,MD   +1 more
doaj  

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source