Results 41 to 50 of about 783,911 (258)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Low expression of Notch1 may be associated with acute myocardial infarction

Frontiers in Cardiovascular Medicine
BackgroundThe transmembrane protein Notch1 is associated with cell growth, development, differentiation, proliferation, apoptosis, adhesion, and the epithelial mesenchymal transition.
Qing Zhang, Qing Zhang, Qing Zhang, Qing Zhang, Heyu Meng, Heyu Meng, Heyu Meng, Heyu Meng, Xue Wang, Xue Wang, Xue Wang, Xue Wang, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Fanbo Meng, Fanbo Meng, Fanbo Meng, Fanbo Meng   +27 more
doaj   +1 more source

Flow mediated dilation in patient with Berlin Heart Incor left ventricle assist device

Monaldi Archives for Chest Disease, 2016
Endothelial function measured with brachial ultrasound (BU) is a validated prognostic factor in heart failure patients. LVAD (left ventricle assist device) application is a promising surgical technique to treat refractory heart failure patients both as a
Franco Tarro Genta, Elena Colajanni, Pierluigi Sbarra, Massimo Tidu, Mauro Rinaldi, Enzo Bosimini   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comparison between Fenugreek and Lovastatin in restoration of endothelial function in an experimental old rat model [PDF]

Acta Medica Iranica, 2003
The aim of this study was to compare the effectiveness of Fenugreek (Trigonella foenum-graecum) with that of lovastatin in restoration of endothelia function in the aorta taken form aged N-Mair rats.
"Pipelzadeh MH, Dezfulian A, Koochek MH, Moradi M "   +3 more
doaj   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Endothelial function in normal and pathological conditions

Медицинский совет, 2019
The article presents the data on the state of endothelial function in the normally and in various diseases and conditions. The basic  functions of endothelium in modulation of vascular tone, atrombogenicity and thrombogenicity of the vascular wall ...
A. V. Pizov, N. A. Pizov, O. A. Skachkova, N. V. Pizovа   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source