Results 41 to 50 of about 745,340 (257)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Low expression of Notch1 may be associated with acute myocardial infarction

Frontiers in Cardiovascular Medicine
BackgroundThe transmembrane protein Notch1 is associated with cell growth, development, differentiation, proliferation, apoptosis, adhesion, and the epithelial mesenchymal transition.
Qing Zhang, Qing Zhang, Qing Zhang, Qing Zhang, Heyu Meng, Heyu Meng, Heyu Meng, Heyu Meng, Xue Wang, Xue Wang, Xue Wang, Xue Wang, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Fanbo Meng, Fanbo Meng, Fanbo Meng, Fanbo Meng   +27 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Comparison between Fenugreek and Lovastatin in restoration of endothelial function in an experimental old rat model [PDF]

Acta Medica Iranica, 2003
The aim of this study was to compare the effectiveness of Fenugreek (Trigonella foenum-graecum) with that of lovastatin in restoration of endothelia function in the aorta taken form aged N-Mair rats.
"Pipelzadeh MH, Dezfulian A, Koochek MH, Moradi M "   +3 more
doaj   +2 more sources

Flow mediated dilation in patient with Berlin Heart Incor left ventricle assist device

Monaldi Archives for Chest Disease, 2016
Endothelial function measured with brachial ultrasound (BU) is a validated prognostic factor in heart failure patients. LVAD (left ventricle assist device) application is a promising surgical technique to treat refractory heart failure patients both as a
Franco Tarro Genta, Elena Colajanni, Pierluigi Sbarra, Massimo Tidu, Mauro Rinaldi, Enzo Bosimini   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Endothelial function in normal and pathological conditions

Медицинский совет, 2019
The article presents the data on the state of endothelial function in the normally and in various diseases and conditions. The basic  functions of endothelium in modulation of vascular tone, atrombogenicity and thrombogenicity of the vascular wall ...
A. V. Pizov, N. A. Pizov, O. A. Skachkova, N. V. Pizovа   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source