Results 61 to 70 of about 1,509,178 (304)

Endothelial nitric oxide synthase transgenic models of endothelial dysfunction [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
Endothelial production of nitric oxide is critical to the regulation of vascular responses, including vascular tone and regional blood flow, leukocyte-endothelial interactions, platelet adhesion and aggregation, and vascular smooth muscle cell proliferation.
Dmitriy N, Atochin, Paul L, Huang
openaire   +2 more sources

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]

, 2006
Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Hopper, RA, Garthwaite, J
core  

Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase [PDF]

Circulation, 1998
Nitric oxide is a principal factor involved in the antiatherosclerotic properties of the endothelium.1 2 3 NO interferes in vitro with key events in the development of atherosclerosis, such as monocyte and leukocyte adhesion to the endothelium4 5 6 7 as well as platelet–vessel wall interaction.8 9 10 NO also decreases endothelial permeability and ...
R. M. F. Wever, T. F. Luscher, COSENTINO, Francesco, T. J. Rabelink   +3 more
openaire   +5 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Endothelial cell dysfunction and nitric oxide synthase [PDF]

Kidney International, 2000
pass graft surgery. Her medical history revealed coronary artery disease, a coronary artery bypass graft four years ago, hypertension, hypothyroidism, a right below-the-knee amputation two years ago, and a left toe amputation one year ago. Last year she underwent left femoral-popliteal bypass graft surgery; during the past four years, she has had ...
openaire   +2 more sources

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress [PDF]

, 2013
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Berkowitz, Dan E, Biljana Musicki, Trinity J Bivalacqua, Musicki Biljana, Berkowitz, DE, Bivalacqua, TJ, Lewis L Hsu, Biljana Musicki (429541), Burnett, Arthur L, Hunter C Champion, Lewis L. Hsu (7926017), Dan E. Berkowitz (7926020), Arthur L. Burnett (7926023), Trinity J. Bivalacqua (7926014), Champion Hunter C., Musicki, Biljana, Burnett Arthur L., Hsu, LL, Hsu Lewis L., Hunter C. Champion (6834875), Bivalacqua Trinity J., Champion, HC, Arthur L Burnett, Hsu, Lewis L, Dan E Berkowitz, Burnett, AL, Champion, Hunter C, Bivalacqua, Trinity J, Berkowitz Dan E., Musicki, B   +29 more
core   +2 more sources

Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels. [PDF]

Int J Gen Med
Charinya Chaichanabut,1 Piyamitr Sritara,2 Jintana Sirivarasai3 1Master of Science Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of ...
Chaichanabut C, Sritara P, Sirivarasai J.   +2 more
europepmc   +2 more sources

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source