Results 41 to 50 of about 1,509,178 (304)

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase [PDF]

, 2009
Proline-rich tyrosine kinase 2 (PYK2) can be activated by angiotensin II (Ang II) and reactive oxygen species. We report that in endothelial cells, Ang II enhances the tyrosine phosphorylation of endothelial NO synthase (eNOS) in an AT1-, H2O2-, and PYK2-
Loot, Annemarieke E., Ingrid Fleming, Annemarieke E. Loot, Fißlthaler, Beate, Fleming, Ingrid, Judith G. Schreiber, Beate Fisslthaler, Schreiber, Judith G.   +7 more
core   +1 more source

Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide

Virology Journal, 2009
This report is the first to demonstrate infection of human endothelial cells by Pichinde virus (PIC). PIC infection induces an upregulation of the inducible nitric oxide synthase gene; as well as an increase in detectable nitric oxide (NO).
Voss Thomas G, Brocato Rebecca L
doaj   +1 more source

Estrogen Modulation of Endothelial Nitric Oxide Synthase [PDF]

Endocrine Reviews, 2002
Abstract Over the past decade, clinical and basic research has demonstrated that estrogen has a dramatic impact on the response to vascular injury and the development of atherosclerosis. Further work has indicated that this is at least partially mediated by an enhancement in nitric oxide (NO) production by the endothelial isoform of NO ...
Ken L, Chambliss, Philip W, Shaul
openaire   +2 more sources

Endothelial Nitric Oxide Synthase [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
This article explores the physiology of superoxide generation by endothelial nitric oxide synthase (eNOS), the so-called “uncoupled” state of the enzyme. The fact that this alternative chemistry of the eNOS enzyme is evolutionary strongly conserved, suggests that it may play a physiological role.
Ton J, Rabelink, Thomas F, Luscher
openaire   +2 more sources

The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats

Kaohsiung Journal of Medical Sciences, 2015
Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats.
Bulent Erol, Tugrul Turker, Adem Tok, Sibel Bektas, Gorkem Mungan, Seyma Ozkanli, Bugra Karakas, Husnu Tokgoz, Bulent Akduman, Aydin Mungan   +9 more
doaj   +1 more source

Nitric oxide produced by endothelial nitric oxide synthase promotes diuresis

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
Extracellular fluid volume is highly regulated, at least in part, by peripheral resistance and renal function. Nitric oxide (NO) produced by NO synthase type 3 (NOS 3) in the nonrenal vasculature may promote fluid retention by reducing systemic vascular resistance and arterial pressure.
Jazmin M, Perez-Rojas, Kamal M, Kassem, William H, Beierwaltes, Jeffrey L, Garvin, Marcela, Herrera   +4 more
openaire   +3 more sources

Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Severe hindlimb ischemia is a chronic disease with poor prognosis that can lead to amputation or even death. This study aimed to assess the therapeutic effect of liraglutide on hind‐limb ischemia in type 2 diabetic mice and to elucidate the ...
Yu‐xin Zhu, Yi Li, Yu Ma, Xiao Zhang, Xingrong Du, Jiali Gao, Nian Hui Ding, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu, Rong Li   +11 more
doaj   +1 more source

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [PDF]

, 2010
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension
Handschin, C, Heinrich, Kathrin, Schäfer, N, Heinrich, K, Winnik, Stephan, Matter, Christian M., Brokopp, Chad E., Tanner, F C, Tanner, Felix C., Landmesser, Ulf, Breitenstein, A, Handschin, Christoph, Stein, Sokrates, Landmesser, U, Lüscher, Thomas F., Breitenstein, Alexander, Schäfer, Nicola, Besler, C, Winnik, S, Lohmann, C, Lüscher, T F, Lohmann, Christine, Besler, Christian, Matter, C M, Brokopp, C E, Stein, S, Landmesser U, Stein S, Lüscher TF, Besler C, Tanner FC, Breitenstein A, Lohmann C, Heinrich K, Matter CM, Winnik S, Brokopp CE, Handschin C, Schäfer N   +38 more
core   +1 more source

Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase

Redox Biology, 2017
Vascular peroxidase 1 (VPO1) is a member of the peroxidase family which aggravates oxidative stress by producing hypochlorous acid (HOCl). Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine
Zhaoya Liu, Yanbo Liu, Qian Xu, Haiyang Peng, Yixin Tang, Tianlun Yang, Zaixin Yu, Guangjie Cheng, Guogang Zhang, Ruizheng Shi   +9 more
doaj   +1 more source

Oxygen Metabolism by Endothelial Nitric-oxide Synthase [PDF]

Journal of Biological Chemistry, 2007
Nitric-oxide synthase (NOS) catalyzes both coupled and uncoupled reactions that generate nitric oxide and reactive oxygen species. Oxygen is often the overlooked substrate, and the oxygen metabolism catalyzed by NOS has been poorly defined. In this paper we focus on the oxygen stoichiometry and effects of substrate/cofactor binding on the endothelial ...
Ying Tong, Gao, Linda J, Roman, Pavel, Martásek, Satya Prakash, Panda, Yuzuru, Ishimura, Bettie Sue S, Masters   +5 more
openaire   +2 more sources