Results 31 to 40 of about 1,509,178 (304)
Endothelial Nitric Oxide Synthase and Heart Rate [PDF]
Circulation, 2002 To the Editor: We read with interest the recent study by Brunner et al,1 which provides compelling evidence that high concentrations of nitric oxide (NO) generated from endothelial nitric oxide synthase (eNOS) overexpression reduces cardiac contraction by decreasing myocardial calcium sensitivity. Their data also suggest that NO has very little effect
Herring, N, Paterson, D
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Effects of NO synthase inhibitors on the synovial microcirculation in the mouse knee joint [PDF]
, 1999 Production of nitric oxide by the inducible NO synthase (iNOS) is known to be enhanced in chronic joint inflammation and osteoarthritis as well as aseptic loosening of joint prostheses.
Refior, H. J. +3 more
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Endothelial Dysfunction in Breast Cancer In-Vivo Model
Proceedings, 2018 Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast ...
Buğra Elkar +9 more
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Biomedicines, 2023 Annually, peripheral arterial disease is estimated to cost over USD 21 billion and diabetic foot disease an estimated at USD 9–13 billion. Mirabegron is a TGA-approved beta-3 adrenoreceptor agonist, shown to be safe and effective in the treatment of ...
Cameron J. F. Evans +3 more
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Tetrahydrobiopterin and Endothelial Nitric Oxide Synthase Uncoupling [PDF]
Hypertension, 2012 To the Editor: Gao et al1 reported that oral administration of folate, the tetrahydrobiopterin (H4B) precursor, attenuated endothelial NO synthase (eNOS) uncoupling in abdominal aortic aneurysm. The beneficial effects of H4B supplementation in endothelial dysfunction are beyond dispute, but in vivo demonstration of eNOS (un)coupling by H4B is very ...
Dimitrios, Tsikas +2 more
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Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]
, 2004 Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy +17 more
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Mìžnarodnij Endokrinologìčnij Žurnal, 2016 The article reviewed the links between polymorphism of endothelial nitric oxide synthase gene (Glu298Asp) and the development and progression of chronic heart failure in patients with ischemic heart disease and obesity.
O.I. Kadykova, P.P. Kravchun
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Scientific Reports, 2021 This study aimed to clarify the role of glypican-1 and PECAM-1 in shear-induced nitric oxide production in endothelial cells. Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein ...
Anne Marie W. Bartosch +5 more
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Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]
, 2003 Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Keaney, John F. +5 more
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Tetrahydrobiopterin and endothelial nitric oxide synthase activity [PDF]
Cardiovascular Research, 1999 Time for primary review 23 days. Nitric oxide (NO) plays a crucial role in the regulation of vascular tone and maintenance of vascular integrity [1–3]. Indeed, nitric oxide reduces vascular tone, inhibits leucocytes adhesion to the endothelium, platelet-vessel wall interaction, as well as vascular smooth muscle cell proliferation and migration ...
Cosentino, Francesco, Lüscher, Thomas F
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