Results 11 to 20 of about 1,509,178 (304)

Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis [PDF]

International Dental Journal
: Objective: While diabetes is known to impair dentin regenerative capacity, the specific role of endothelial nitric oxide synthase (eNOS) is poorly defined. This study aimed to elucidate how eNOS regulates the osteo/odontogenic differentiation of human
Xuanhe Feng, Liang Hu, Chen Zhang, Wanzhen Lei, Bowen Zhou, Dengsheng Xia, Zhaochen Shan, Luyuan Jin   +7 more
doaj   +2 more sources

Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism [version 1; peer review: 3 approved] [PDF]

F1000Research, 2020
Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human body. The signaling functions of nitric oxide are accomplished through two primer mechanisms: cGMP-mediated phosphorylation and the formation of S-nitrosocysteine ...
Margarita Tenopoulou, Paschalis-Thomas Doulias   +1 more
doaj   +3 more sources

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The mechanisms determining vascular tone are still not completely understood, even though it is a significant factor in blood pressure management. Many circulating proteins have a significant impact on controlling vascular tone.
Ariane Bruder‐Nascimento, Wanessa M. C. Awata, Juliano V. Alves, Shubhnita Singh, Rafael M. Costa, Thiago Bruder‐Nascimento   +5 more
doaj   +2 more sources

L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells

Pulmonary Circulation, 2021
The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass, Yongmei Zhang, Mark R. Kaplowitz, Candice D. Fike   +3 more
doaj   +1 more source

ACTIVITY MODULATION OF VARIOUS NITRIC OXIDE SYNTASES AS AN APPROACH TO ENDOTHELIAL DYSFUNCTION THERAPY

Фармация и фармакология (Пятигорск), 2022
Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted the attention of researchers at the end of the 19th century.
D. V. Kurkin, E. E. Abrosimova, D. A. Bakulin, N. S. Kovalev, M. A. Dubrovina, A. V. Borisov, A. V. Strygin, E. I. Morkovin, I. N. Tyurenkov   +8 more
doaj   +1 more source

Endothelial nitric oxide synthase in the microcirculation [PDF]

Cellular and Molecular Life Sciences, 2015
Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide (NO)--a key molecule that can directly (or indirectly) act as a vasodilator and anti-inflammatory mediator. In this review, we examine the structural effects of regulation of the eNOS enzyme, including post-translational modifications and subcellular localization ...
Xiaohong, Shu, T C Stevenson, Keller, Daniela, Begandt, Joshua T, Butcher, Lauren, Biwer, Alexander S, Keller, Linda, Columbus, Brant E, Isakson   +7 more
openaire   +2 more sources

Inhibition of Endothelial Nitric-oxide Synthase by Ceruloplasmin [PDF]

Journal of Biological Chemistry, 1999
The plasma copper protein ceruloplasmin (CP) was found to inhibit endothelial nitric-oxide synthase activation in cultured endothelial cells, in line with previous evidence showing that the endothelium-dependent vasorelaxation of the aorta is impaired by physiological concentrations of ceruloplasmin.
BIANCHINI A., MUSCI, Giovanni, CALABRESE L.   +2 more
openaire   +4 more sources

Pro- and anti-fibrotic effects of vascular endothelial growth factor in chronic kidney diseases

Renal Failure, 2022
Renal fibrosis is the inevitable common end-point of all progressive chronic kidney diseases. The underlying mechanisms of renal fibrosis are complex, and currently there is no effective therapy against renal fibrosis.
Changxiu Miao, Xiaoyu Zhu, Xuejiao Wei, Mengtuan Long, Lili Jiang, Chenhao Li, Die Jin, Yujun Du   +7 more
doaj   +1 more source

Molecular mechanisms and modulation of Endothelial Progenitor Cell function in South Asian men [PDF]

, 2012
South Asian ethnicity has long been considered a contributory factor in the development of atherosclerosis and cardiovascular disease. Endothelial dysfunction is considered to be the precursor of atherosclerosis, and South Asian ethnicity has been linked
Baliga, Vivek
core   +5 more sources

Comparison of the antihypertensive effects of folic acid and resveratrol in spontaneously hypertensive rats combined with hyperhomocysteinemia

SAGE Open Medicine, 2023
Objectives: Studies have found that both folic acid and resveratrol have potential benefits in reducing complications of hypertension. The aim of this study was to compare the effects of resveratrol and folic acid on blood pressure in spontaneously ...
Yi Lu, Lihua Zhang, Chunli Wang, Chunbo Gong   +3 more
doaj   +1 more source