Results 51 to 60 of about 1,509,178 (304)

Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine. [PDF]

, 2003
Background— Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to increased expression and enzymatic activity of both the constitutive and inducible ...
Cartwright, JE, Stephen S. Nussey, Whitley, GS, Guy St J. Whitley, Holden, DP, Desmond P. Holden, Nussey, SS, Judith E. Cartwright   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Role of Endothelial Nitric Oxide Synthase in Endothelial Cell Migration [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1999
Abstract —Endothelium-derived nitric oxide (NO) and its precursor l -arginine have been implied to promote angiogenesis, but little is known about the precise mechanism. The inhibition of endogenous NO formation by N ω -nitro -l -arginine methyl
T, Murohara, B, Witzenbichler, I, Spyridopoulos, T, Asahara, B, Ding, A, Sullivan, D W, Losordo, J M, Isner   +7 more
openaire   +2 more sources

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population.

, 2011
In an analysis of the possible association of endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and plasma nitric oxide levels in patients with acute coronary syndrome, we investigated 106 patients with the syndrome and 100 healthy
Sai Babu, R., Gururajan, P., Sarasa Bharati, A., Victor, D., Cherian, K.M., Gurumurthy, P., Srinivasa Nageswara, R.ao G   +6 more
core   +1 more source

Antiobesogenic Role of Endothelial Nitric Oxide Synthase [PDF]

, 2014
The prevalence of obesity has increased remarkably in the past four decades. Because obesity can promote the development of type 2 diabetes and cardiovascular disease, understanding the mechanisms that engender weight gain and discovering safe antiobesity therapies are of critical importance. In particular, the gaseous signaling molecule, nitric oxide (
Brian E, Sansbury, Bradford G, Hill
openaire   +2 more sources

Salt Inactivates Endothelial Nitric Oxide Synthase in Endothelial Cells [PDF]

The Journal of Nutrition, 2009
There is a 1-4 mmol/L rise in plasma sodium concentrations in individuals with high salt intake and in patients with essential hypertension. In this study, we used 3 independent assays to determine whether such a small increase in sodium concentrations per se alters endothelial nitric oxide synthase (eNOS) function and contributes to hypertension.
Juan, Li, James, White, Ling, Guo, Xiaomin, Zhao, Jiafu, Wang, Eric J, Smart, Xiang-An, Li   +6 more
openaire   +2 more sources

Magnetoactive Hydrogels to Probe Curvature‐Directed Endothelial Cell Mechanosensing

Advanced Healthcare Materials, EarlyView.
This work establishes a platform to investigate local curvature as a regulator of endothelial mechanosensing independent of shear stress. Magnetoactive hydrogels enable on‐demand curvature of endothelial monolayers to reproduce tortuosity quantified by clinically established metrics.
Avinava Roy, Grace K. Hinds, Joshua Yu‐Chung Liu, Ziqian Yang, Rishab Yanala, Arina E. Velieva, Claudia Loebel   +6 more
wiley   +1 more source

The effect of the dietary constituent conjugated linoleic acid and homocysteine on vascular endothelial cell function [PDF]

, 2004
The interaction between circulating dietary constituents and the vascular endothelial monolayer is vital to the proper maintenance o f vascular homeostatic mechanisms, such as vasoregulation. Endothelial dysfunction with subsequent loss of vasoregulatory
Coen, Paul Martin
core   +2 more sources