Results 301 to 310 of about 268,157 (315)

Extracellular vesicles derived from endothelial progenitor cells modified by Houshiheisan promote angiogenesis and attenuate cerebral ischemic injury via miR-126/PIK3R2. [PDF]

Sci Rep
Zhang Y, Yang Q, Cheng H, Zhang Y, Xie Y, Zhang Q.   +5 more
europepmc   +1 more source

Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation

Sensory Neuroscience, EarlyView.
ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera, Nicole Ramones, Isabella Moceri, Sanjoy K. Bhattacharya   +3 more
wiley   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Fabricating Microfluidic Co‐Cultures of Immortalized Cell Lines Uncovers Robust Design Principles for the Simultaneous Formation of Patterned, Vascularized, and Stem Cell‐Derived Adipose Tissue

Small, EarlyView.
Murphy et al present an optimized co‐culture protocol for immortalized cell line vasculogenesis. Here, immortalized co‐cultures form reproducible microvessel networks across 31‐days, while gradient microchips enable simultaneous mesenchymal stem cell (MSC) adipogenesis and endothelial cell (EC) vasculogenesis.
Ashley R. Murphy, Rose Ann Franco, Mark C. Allenby   +2 more
wiley   +1 more source

Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway. [PDF]

Open Med (Wars)
Tan C, Chen J, Tu T, Chen L, Zou J.
europepmc   +1 more source

Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma

Small Science, EarlyView.
This review critically evaluates current state‐of‐the‐art in vitro glioma models especially glioma‐on‐a‐chip models based on readout capability, performance, and physiological relevance. It summarizes the key parameters and proposes a practical framework to guide researchers in selecting the most suitable preclinical models for glioma studies.
Su Liu, Zhenyu Gong, Dairan Zhou, Vanesa Ayala‐Nunez, Tao Xu, Peter Wick   +5 more
wiley   +1 more source

Hsa-miR-134-5p predicts cardiovascular risk in circulating mononuclear cells and improves angiogenic action of senescent endothelial progenitor cells. [PDF]

J Cell Mol Med
Tien TY, Wu YJ, Chang CY, Hung CL, Lee YN, Lee HI, Chou YH, Lin CF, Lee CW, Su CH, Yeh HI.   +10 more
europepmc   +1 more source

Human Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo‐Epidermal Skin Substitutes

Small Methods, EarlyView.
This study unveils a pioneering approach to bioengineering of human skin substitutes with distinct arterial and venous capillaries. Combining single‐cell transcriptomics and 3D hydrogel models, this work reveals unique endothelial marker dynamics in fetal and juvenile skin.
Dominic Rütsche, Monica Nanni, Phil Cheng, Nicolà Caflisch, Aizhan Tastanova, Céline Jenni, Mitchell P. Levesque, Ueli Moehrlen, Agnes S. Klar, Thomas Biedermann   +9 more
wiley   +1 more source

Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway. [PDF]

Mol Med Rep
Zhang X, Wang S, Qin Y, Guo H.
europepmc   +1 more source

The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High‐Resolution Live Cell Microscopy

Small Methods, EarlyView.
Mechanical strain influences tissue development, homeostasis, and disease. The TissueTractor, a high‐strain stretcher system, enables high‐resolution imaging of live tissues and cells under strain, revealing cellular strain heterogeneity, cytoskeletal remodeling, and morphological adaptations in various model systems.
Jing Yang, Emily Hearty, Yingli Wang, Deepthi S. Vijayraghavan, Timothy Walter, Sommer Anjum, Carsten Stuckenholz, Ya‐Wen Cheng, Sahana Balasubramanian, Yicheng Dong, Adam V. Kwiatkowski, Lance A. Davidson   +11 more
wiley   +1 more source