Results 91 to 100 of about 430,240 (358)

Arteriogenesis versus angiogenesis: similarities and differences [PDF]

, 2007
Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical ...
Eitenmüller, Inka, Heil, Matthias, Schaper, Wolfgang, Schmitz-Rixen, Thomas   +3 more
core   +1 more source

Functional Characterization of Embryonic Stem Cell-Derived Endothelial Cells [PDF]

Journal of Vascular Research, 2011
Endothelial cells (EC) derived from embryonic stem cells (ESC) require additional functional characterization before they are used as a cell therapy in order to enhance their potential for engraftment and proliferation. We explore several physiologically relevant functions of ESC-derived EC (ESC-EC), such as its capacity to produce nitric oxide (NO ...
Glaser, Drew E., Gower, Robert M., Lauer, Nicholas E., Tam, Kayan, Blancas, Alicia A., Shih, Albert J., Simon, Scott I., McCloskey, Kara E.   +7 more
openaire   +3 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke

Neural Regeneration Research
Adipose-derived stem cell, one type of mesenchymal stem cells, is a promising approach in treating ischemia-reperfusion injury caused by occlusion of the middle cerebral artery.
Zhijian Zheng, Xiaohui Lin, Zijun Zhao, Qiang Lin, Ji Liu, Manli Chen, Wenwen Wu, Zhiyun Wu, Nan Liu, Hongbin Chen   +9 more
doaj   +1 more source

Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells

Stem Cells International, 2019
Urine has become the source of choice for noninvasive renal epithelial cells and renal stem cells which can be used for generating induced pluripotent stem cells.
Lisa Nguyen, Lucas-Sebastian Spitzhorn, James Adjaye   +2 more
doaj   +1 more source

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates

Biomedical Journal, 2019
Background: Micro-mass culturing or cellular aggregation is an effective method used to form mineralised bone tissue. Poor core cell viability, however, is often an impeding characteristic of large micro-mass cultures, and equally for large tissue ...
Anthony J. Deegan, Wim J. Hendrikson, Alicia J. El Haj, Jeroen Rouwkema, Ying Yang   +4 more
doaj   +1 more source

Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Cells [PDF]

Current Protocols in Human Genetics, 2018
AbstractEndothelial cells (ECs) line the interior surface of blood and lymphatic vessels, and play a key role in a variety of physiological or pathological processes such as thrombosis, inflammation, or vascular wall remodeling. Human‐induced pluripotent stem cell (iPSCs)‐derived ECs provide a new opportunity for vascular regeneration and serve as a ...
Mingxia Gu, Mingxia Gu
openaire   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Host-microbe interactions at the blood-brain barrier through the lens of induced pluripotent stem cell-derived brain-like endothelial cells

mBio
Microbe-induced meningoencephalitis/meningitis is a life-threatening infection of the central nervous system (CNS) that occurs when pathogens are able to cross the blood-brain barrier (BBB) and gain access to the CNS.
Nadine Vollmuth, Jon Sin, Brandon J. Kim
doaj   +1 more source

Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome

Data in Brief, 2019
The data and information presented here refer to the research article entitled: “Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting with the human amniotic fluid stem cell secretome” (Balbi et al., 2019, Apr 04).
Carolina Balbi, Kirsten Lodder, Ambra Costa, Silvia Moimas, Francesco Moccia, Tessa van Herwaarden, Vittorio Rosti, Francesca Campagnoli, Agnese Palmeri, Pierangela De Biasio, Francesco Santini, Mauro Giacca, Marie-Josè Goumans, Lucio Barile, Anke M. Smits, Sveva Bollini   +15 more
doaj   +1 more source