Mobilization of bone marrow-derived progenitor cells in acute coronary syndromes.
Two hypotheses explain the role of adult progenitor cells in myocardial regeneration. Stem cell plasticity which involves mobilization of stem cells from the bone marrow and other niches, homing to the area of tissue injury and transdifferentiation into ...
Wojciech Wojakowski, Michał Tendera
doaj +1 more source
Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R.+4 more
core +1 more source
Background To cure ischemic diseases, angiogenesis needs to be improved by various strategies in ischemic area. Considering that microRNA-132 (miR-132) regulates endothelial cell behavior during angiogenesis and the safe and efficacious delivery of ...
T. Ma+11 more
semanticscholar +1 more source
Biophysical regulation of stem cell behavior within the niche. [PDF]
Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure and function, these cells require extensive ...
Conway, Anthony, Schaffer, David V
core +1 more source
Human pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties
The authors differentiate human stem cells to brain pericyte–like cells and integrate them into a neurovascular unit model. Brain pericytes play important roles in the formation and maintenance of the neurovascular unit (NVU), and their dysfunction has ...
Matthew J. Stebbins+9 more
semanticscholar +1 more source
E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells [PDF]
RATIONALE: The majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major ...
Boriboun, Chan+17 more
core +1 more source
Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos.
Chloé S Baron+9 more
semanticscholar +1 more source
Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes during Cardiac Homeostasis
Cardiac tissue undergoes renewal with low rates. Although resident stem cell populations have been identified to support cardiomyocyte turnover, the source of the cardiac stem cells and their niche remain elusive. Using Cre/Lox-based cell lineage tracing
Bryan A. Fioret+3 more
doaj +1 more source
Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver. [PDF]
Rahmawati FN+6 more
europepmc +1 more source
CXCR4 pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis [PDF]
There is still controversy regarding the role of circulating endothelial and progenitor cells (CECs/CEPs) in the pathogenesis of systemic sclerosis (SSc).
CAMPIONI, Diana+8 more
core +2 more sources