Results 141 to 150 of about 5,863,268 (295)

Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors.

PLoS ONE, 2014
Human embryonic stem cell-derived endothelial cells (hESC-EC), as well as other stem cell derived endothelial cells, have a range of applications in cardiovascular research and disease treatment.
Daniel M Reed, Gabor Foldes, Timothy Gatheral, Koralia E Paschalaki, Zsuzsanna Lendvai, Zsolt Bagyura, Tamas Nemeth, Judit Skopal, Bela Merkely, Aurica G Telcian, Leila Gogsadze, Michael R Edwards, Peter J Gough, John Bertin, Sebastian L Johnston, Sian E Harding, Jane A Mitchell   +16 more
doaj   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space

Advanced Materials Technologies, EarlyView.
Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Finn Dani, Constantin Greil, Sarah Duin, Anja Lode, Michael Gelinsky   +7 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science
Identifying the drivers of cellular senescence that contribute to the decline in vascular function with age and disease is critical for developing restorative interventions. Here, we investigated how increased mechanical stress from extracellular matrix (
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
doaj   +1 more source

Cancer Stem Cells and Endothelial Cells: An Ancient But Timeless Cooperation

In Vivo
Cancer stem cells (CSCs) are a highly tumorigenic cell population present in many malignancies and cancer cell lines, frequently exhibiting resistance to conventional chemotherapeutic agents. In this brief review, we discuss the ability CSCs to transdifferentiate into endothelial cells by expressing markers of the vascular endothelium. We highlight the
RIBATTI, DOMENICO, CIMPEAN, ANCA MARIA
openaire   +3 more sources

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source