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Pharmacological Reviews, 2016 The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype.
A. Davenport +8 more
semanticscholar +4 more sources
The Effect of Autologous Dendritic Cell Therapy on Renal Perfusion in Diabetic Kidney Disease: Analysis of Doppler Ultrasound and Angiogenesis Biomarkers [PDF]
DiseasesBackground: Diabetes mellitus (DM) is a global health challenge with a severe health burden. Approximately 40% of diabetic patients develop diabetic kidney disease (DKD), leading to kidney failure.
Ardianto Pramono +6 more
doaj +2 more sources
Endothelin and Endothelin Antagonists in Chronic Kidney Disease [PDF]
Kidney International, 2014 The incidence and prevalence of chronic kidney disease (CKD), with diabetes and hypertension accounting for the majority of cases, is on the rise, with up to 160 million individuals worldwide predicted to be affected by 2020. Given that current treatment
D. Kohan, M. Barton
semanticscholar +4 more sources
Digestion, 1998 Accessible online at: http://BioMedNet.com/karger Hyperdynamic circulation as well as increased hepatic resistance contribute to portal hypertension in cirrhosis of the liver [1]. Hyperdynamic circulation with increased cardiac output, heart rate and plasma volume and decreased arterial blood pressure and systemic vascular resistance are characteristic
Bilzer, Manfred +2 more
core +4 more sources
Differentiation of endothelin-1 and endothelin-3 concentrations [PDF]
Gastroenterology, 1993 Inhaltsverzeichnis ...
Gerbes, Alexander L.
core +3 more sources
Endothelin Receptors and Their Antagonists
Seminars in Nephrology, 2015 All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
J. Maguire, A. Davenport
semanticscholar +5 more sources
Early Administration of Bosentan in High‐Risk COVID‐19 Outpatients at Risk of Sarcopenia: A Randomized, Double‐Blind, Placebo‐Controlled Trial [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Endothelial damage induces myofibrillar breakdown and muscle degradation in COVID‐19 infection. There is a relationship between increased endothelin‐1 synthesis and sarcopenia. We evaluated the preventive effect of early bosentan therapy as an
Shaahin Shahbazi +3 more
doaj +2 more sources
Endothelin-1 level as a predictor of hepatopulmonary syndrome in liver cirrhosis [PDF]
Medicinski Glasnik, 2020 Aim To determine the role of endothelin (ET)-1 in predicting hepatopulmonary syndrome (HPS) in patients with liver cirrhosis. Methods A cross sectional study involving 80 liver cirrhosis patients aged 18 years or older was conducted in Adam Malik ...
Darmadi, Riska Habriel Ruslie
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Cells, 2023 Glioblastoma (GBM) is the most common and aggressive type of brain tumor due to its elevated recurrence following treatments. This is mainly mediated by a subpopulation of cells with stemness traits termed glioblastoma stem-like cells (GSCs), which are ...
Ignacio Niechi +17 more
doaj +1 more source
Bosentan, a drug used in the treatment of pulmonary hypertension, can prevent development of osteoporosis [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods.Materials and Methods: Rats were divided into 4 groups of 8 rats each: one control (Sham), one osteoporosis only (OP), and ...
Duygu Köse +6 more
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