Results 41 to 50 of about 23,747,035 (396)

Role of endothelin-1 in periodontal diseases: A structured review

Indian Journal of Dental Research, 2016
Background and Objective: Endothelin-1 (ET-1) is a 21-amino acid peptide and is a potent vasoconstrictor produced by endothelial cells. It plays a role in the development of diseases such as hypertension and atherosclerosis.
Waleed Khalid, Sheeja Vargheese, Reema Lakshmanan, M. Sankari, N. Jayakumar   +4 more
semanticscholar   +1 more source

The Structural Features of Vascular Endothelium in Acute Cerebral Ischemia [PDF]

, 2017
The aim of the research was to study the number and structural properties of desquamated endothelial cells (DECs) in the peripheral blood in carotid ischemic stroke (CIS) and carotid transient ischemic attacks (TIAs) and its connection with the marker of
Kosheleva, A. (Anna)
core   +2 more sources

High endothelin-converting enzyme-1 expression independently predicts poor survival of patients with esophageal squamous cell carcinoma

Tumor Biology, 2017
Patients with esophageal squamous cell carcinoma have poor survival and high recurrence rate, thus an effective prognostic biomarker is needed. Endothelin-converting enzyme-1 is responsible for biosynthesis of endothelin-1, which promotes growth and ...
Ching-Fang Wu, Ching-Tai Lee, Yao-Hung Kuo, Tzu-Haw Chen, Chi-Yang Chang, I-Wei Chang, Wen-Lun Wang   +6 more
doaj   +1 more source

Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction

Cellular Physiology and Biochemistry, 2017
Background/Aims: Endothelin-1 is implicated in the pathogenesis of hypertension, but the underlying mechanisms remained elusive. Our previous study found that inhibition of mitochondrial fission of smooth muscle cells suppressed phenylephrine- and high K+
Chang Chen, Jin-Lai Gao, Ming-Yu Liu, Shan-Liang Li, Xiu-Chen Xuan, Xin-Zi Zhang, Xi-Yue Zhang, Yuan-Yuan Wei, Chang-Lin Zhen, Jing Jin, Xin Shen, De-Li Dong   +11 more
doaj   +1 more source

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.

Journal of the American Society of Nephrology, 2016
Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the mechanisms underlying the protective effect remain unknown.
M. Garsen, O. Lenoir, A. Rops, H. Dijkman, Brigith K. Willemsen, T. V. van Kuppevelt, T. Rabelink, J. Berden, P. Tharaux, J. van der Vlag   +9 more
semanticscholar   +1 more source

p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists [PDF]

, 2012
Extracellular signal-regulated kinases 1/2 (ERK1/2) and their substrates, p90 ribosomal S6 kinases (RSKs), phosphorylate different transcription factors, contributing differentially to transcriptomic profiles.
Adachi, Angela Clerk, Bhatt, Bueno, Cargnello, Casar, Chen, Chen, Choi, Chuderland, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Cuello, Cullingford, Davies, Di, Doehn, Dokladda, Emre Amirak, Gao, Gillespie-Brown, Giraldo, Jensen, Kehat, Kennedy, Knepper, Lips, Lorenz, Marshall, Moor, Peter H. Sugden, Romeo, Sapkota, Stephen J. Fuller, Sugden, Sugden, Turjanski, Valks, Yue   +43 more
core   +1 more source

Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study [PDF]

, 2016
Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that shows an association between ...
Bertolotto, Patricia Isolina, Dotto, Gladys, Garutti, Alicia, Herrera, Jimena María, Lassen, Oscar, Ojeda, Silvia, Sembaj, Adela, Tabares, Sandra   +7 more
core   +2 more sources

Association of Elevated Plasma Endothelin-1 Levels With Pulmonary Hypertension, Mortality, and Heart Failure in African American Individuals: The Jackson Heart Study.

JAMA cardiology, 2016
IMPORTANCE Despite pathophysiological links between endothelin-1 and pulmonary vascular remodeling, to our knowledge, the association between plasma endothelin-1 levels and pulmonary hypertension has not been studied in the general population.
M. Jankowich, Wen‐Chih Wu, G. Choudhary   +2 more
semanticscholar   +1 more source

Role of endothelin in the pathophysiology of renal ischemia-reperfusion in normal rabbits [PDF]

, 1996
Role of endothelin in the pathophysiology of renal ischemia-reperfusion in normal rabbits. The present study addressed the acute effects of endothelin-1 on renal function and neutrophils accumulation in the setting of in vivo severe (60 min) acute ...
Caramelo, Carlos, Casado, Santos, Cernadas, María Rosa, Digiuni, Enzo, Espinosa, Gaudencio, Farré, Antonio López, Hernando, Luis, Manzarbeitia, Felix, Millás, Inmaculada, Montón, Mercedes, Mosquera, Juan R., Tan, Dunyong   +11 more
core   +1 more source

Differentiation of endothelin-1 and endothelin-3 concentrations [PDF]

, 1993
Inhaltsverzeichnis ...
Gerbes, Alexander L.
core   +1 more source