Results 91 to 100 of about 91,462 (235)
, 2007 Background: Endothelin-1 is elevated in heart failure (HF) and after acute myocardial infarction (AMI) and gives prognostic information on mortality. Another part of its precursor, C-terminal Pro-Endothelin-1 (CT-proET-1), is more stable in circulation ...
Ian B. Squire (7583342) +8 more
core +5 more sources
Relevância da formação de endotelina -1(1-31) na mediação do efeito nociceptivo da big endotelina-1 em camundongos: [dissertação] [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Farmacologia.The nociceptive effects of Endothelin-1 (ET) are well-known. This peptide is synthesized by cleavage of Big ET-1 by
Somensi, Amélia Regina
core
iNew Medicine, EarlyView.Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong +15 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Right ventricular (RV) to left ventricular (LV) end‐diastolic volume ratio (RV/LV) is a validated marker of RV dilation in pulmonary arterial hypertension (PAH), yet its impact on LV myocardial function and the underlying mediating pathway is incompletely characterized.
Han Fang +11 more
wiley +1 more source
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]
, 2009 Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Noriko N. Okada +7 more
core
Biochemische und funktionelle Charakterisierung zellfrei exprimierter G-Protein-gekoppelter Rezeptoren des humanen Endothelin-Systems [PDF]
, 2011 G-protein coupled receptors (GPCRs) are the key players in signal perception and transduction and one of the currently most important class of drug targets.
Junge, Friederike Alessandra
core
Obesity, EarlyView.ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour +9 more
wiley +1 more source
Endothelin-1 release by endothelial cells stimulated with B2R and D2R agonists.
, 2018 Confluent cell cultures were preincubated with 10 ng/ml TNF-α for 6 hours, followed by stimulation with 100 nM BK, 100 nM SUM, or both agonists simultaneously for 24 hours and the ET-1 concentration was measured by ELISA. The bars present the mean values
Andrzej Kozik (5963546) +2 more
core +1 more source
Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions
Portal Hypertension &Cirrhosis, EarlyView.This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley +1 more source