Results 161 to 170 of about 213,552 (385)

The Prevalence and Severity of Pain in Patients With Systemic Sclerosis

The Journal of Dermatology, EarlyView.
ABSTRACT We investigated pain prevalence and severity in systemic sclerosis (SSc) and patient–physician perceptions. This was an internet‐based survey that compared perceptions of pain type, location, severity, associated factors between patients with SSc and physicians, and pain treatment prescription patterns in Japan in March 2023.
Sei‐ichiro Motegi, Mona Uchida‐Yamada, Yoshihito Shima, Taku Shimada, Haruka Ishii, Yoshito Ohya, Yasumasa Kanai   +6 more
wiley   +1 more source

THE INVOLVEMENT OF ENDOTHELIAL DYSFUNCTION MARKERS IN THE PATHOGENESIS OF CHRONIC GLOMERULONEPHRITIS

Вопросы современной педиатрии, 2006
Chronic glomerulonephritis remains the leading cause of formation of chronic renal insufficiency, which creates the necessity of looking for new ways of the progress impediment.
T.V. Margieva, T.V. Sergeeva
doaj  

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. [PDF]

, 1989
Katsutoshi Goto, Yoshitoshi Kasuya, Norio Matsuki, Yoh Takuwa, Hiroki Kurihara, Tomohisa Ishikawa, Sadao Kimura, Masashi Yanagisawa, Takao Masaki   +8 more
openalex   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring

Alcohol, Clinical and Experimental Research, EarlyView.
Adults with prenatal alcohol exposure (PAE) are at increased risk for metabolic, immune, and cardiovascular disease. Little is known about the contribution of PAE to cerebrovascular disease, specifically during middle age, a time when stroke incidence and severity typically increase.
Shameena Bake, Marisa R. Pinson, David A. Hurst, Brendan O'Reilly, Nadia Samiya, Rajesh C. Miranda, Farida Sohrabji   +6 more
wiley   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Early Administration of Bosentan in High‐Risk COVID‐19 Outpatients at Risk of Sarcopenia: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Journal of Cachexia, Sarcopenia and Muscle
Background Endothelial damage induces myofibrillar breakdown and muscle degradation in COVID‐19 infection. There is a relationship between increased endothelin‐1 synthesis and sarcopenia. We evaluated the preventive effect of early bosentan therapy as an
Shaahin Shahbazi, Erfan Shahbazi, Farid Zayeri, Zahra Vahdat Shariatpanahi   +3 more
doaj   +1 more source

Three apparent receptor subtypes for the endothelin/sarafotoxin family [PDF]

, 1989
Yoel Kloog, D. Bousso-Mittler, Avner Bdolah, Mordechai Sokolovsky   +3 more
openalex   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source