Results 11 to 20 of about 208,585 (381)
Cellular and Molecular Life Sciences, 2010 Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was originally isolated and characterized from the culture media of aortic endothelial cells. Two other isoforms, termed endothelin-2 and endothelin-3, were subsequently identified, along with structural homologues isolated from the venom of Actractapis engaddensis known
Kawanabe, Yoshifumi, Nauli, Surya M.
openaire +4 more sources
Biomedicines, 2021 The endothelium is the single-cell monolayer that lines the entire vasculature. The endothelium has a barrier function to separate blood from organs and tissues but also has an increasingly appreciated role in anti-coagulation, vascular senescence ...
Peter J. Little +3 more
doaj +1 more source
Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy
Journal of Clinical Medicine, 2020 The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin receptor antagonists (ERAs), such as bosentan, ambrisentan, or macitentan,
Frederik C Enevoldsen +5 more
semanticscholar +1 more source
Bagcilar Medical Bulletin, 2020 Objective:This study aimed to determine the changes in endothelin and von Willebrand factor (vWF) serum levels during early period aneurysmal subarachnoid hemorrhage (SAH) compared to healthy individuals and to analyze them according to clinical and ...
Serkan Kitiş +2 more
doaj +1 more source
Endothelin-1 in systemic sclerosis
Indian Dermatology Online Journal, 2012 Introduction: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis.
Mehrdad Aghaei +7 more
doaj +1 more source
Endothelin-3 like immunoreactivity in plasma of patients with cirrhosis of the liver [PDF]
, 1992 A highly specific and sensitive radioimmunoassay (RIA) has been established for determination of endothelin-3 like immunoreactivity in human plasma to investigate its possible role in hemodynamic alterations due to liver disease.
Alexander L. Gerbes +18 more
core +1 more source
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin [PDF]
, 2010 Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein ...
Clerk, Angela +5 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1989 Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endothelin sequence.
A. Inoue +6 more
semanticscholar +1 more source
Gnaq and Gna11 in the Endothelin signaling pathway and melanoma
Frontiers in Genetics, 2016 In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz +1 more
doaj +1 more source
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]
, 2008 Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali +7 more
core +1 more source