Results 221 to 230 of about 90,498 (305)

Integrated Network Pharmacology, Single‐Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Aortic dissection is a life‐threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi‐target and multi‐pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single‐cell transcriptomics and experimental validation.
Zhaomeng Wang   +10 more
wiley   +1 more source

Effects of aprocitentan on prognostically relevant ambulatory blood pressure-derived variables in resistant hypertension. [PDF]

open access: yesJ Hypertens
Schlaich MP   +6 more
europepmc   +1 more source

Endothelin ETB Receptors Couple to Two Distinct Signaling Pathways in Porcine Kidney Epithelial LLC-PK1 Cells.

open access: diamond, 1994
Satoshi Ozaki   +4 more
openalex   +1 more source

Current Status of Research on Losartan in Tumour Therapy

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1. [PDF]

open access: yesEpigenomics
García-Carmona S   +11 more
europepmc   +1 more source

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

open access: yesJournal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi   +4 more
wiley   +1 more source

Endothelin-1 does not alter Ca2+ responsiveness in saponin-skinned ferret papillary muscles

open access: hybrid, 1994
George Y. Paik   +3 more
openalex   +1 more source

Home - About - Disclaimer - Privacy