Results 21 to 30 of about 208,585 (381)

Endothelin and the podocyte [PDF]

Clinical Kidney Journal, 2012
In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Matthias Barton, Pierre-Louis Tharaux
openaire   +3 more sources

Transient Mesenteric Ischemia Leads to Remodeling of Rat Mesenteric Resistance Arteries

Frontiers in Physiology, 2012
Mesenteric ischemia/reperfusion (I/R) is associated with high rates of morbidity and mortality. We studied the effect of mesenteric I/R on structural and mechanical properties of rat mesenteric resistance artery (MRA) that, once disrupted, might impact ...
Laura eCaracuel, Francesc eJiménez-Altayó, Monica eRomo, Ana eMárquez, Ana P Dantas, Elisabet eVila   +5 more
doaj   +1 more source

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]

, 2008
Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad, Andrew K. Marshall, Angela Clerk, Atkins, Bieker, Bilanges, Bogoyevitch, Boon, Chen, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Cook, Cullingford, Dang, Davies, Dorn, El Li Tham, Favata, Feinberg, Fisch, Ghaleb, Haldar, Hamik, Harrison, Inuzuka, Iwaki, Kaczynski, Kawai-Kowase, Kemp, Kennedy, Kojima, Kyriakis, Lavallée, Leung, Liu, Lomberk, Markou, Matthew J. Butler, Mody, Moriguchi, Ornatsky, Peter H. Sugden, Pham, Pham, Scohy, Sohn, Sugden, Sun, Suske, Suzuki, Timothy E. Cullingford, Uchida, van Thienen, van Vliet, Wani, Yang   +61 more
core   +2 more sources

Endothelin: 30 Years From Discovery to Therapy.

HYPERTENSION, 2019
Discovered in 1987 as a potent endothelial cell-derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional peptide with cytokine-like activity contributing to ...
M. Barton, M. Yanagisawa
semanticscholar   +1 more source

Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection. [PDF]

, 2016
BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis.
AH Chester, Amanda S. Heringer, B Degano, B Degano, BJ Kircher, C Rubens, D Iglesias, D Shao, DB Badesch, F Bohm, F Leyva, G Barbaro, G Zou, GD Kanmogne, H Ehrenreich, H Nunes, James West, JD Rich, Jeffrey N. Martin, John S. Macgregor, LJ Rubin, M Berger, M Nootens, M Opravil, M Opravil, M Yoshibayashi, MQ Feijoo, MR Fisher, MT Gladwin, N Galie, N Galie, O Sitbon, O Sitbon, Peter Ganz, Priscilla Y. Hsue, PY Hsue, R Tibshirani, Rebecca Scherzer, RJ Oudiz, RN Channick, RN Channick, Rushi V. Parikh, RV Parikh, RV Parikh, S Almodovar, S Almodovar, S Shapiro, Steven G. Deeks, T Thenappan, VN Selby, VV McLaughlin, Yifei Ma   +51 more
core   +8 more sources

Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study [PDF]

, 2016
Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that shows an association between ...
Bertolotto, Patricia Isolina, Dotto, Gladys, Garutti, Alicia, Herrera, Jimena María, Lassen, Oscar, Ojeda, Silvia, Sembaj, Adela, Tabares, Sandra   +7 more
core   +2 more sources

Immune Mechanisms Linking Obesity and Preeclampsia

Biomolecules, 2015
Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal morbidity and mortality in developing countries and its pervasiveness is increasing within ...
Frank T. Spradley, Ana C. Palei, Joey P. Granger   +2 more
doaj   +1 more source

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

New England Journal of Medicine, 1993
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells in the walls of small pulmonary arteries.
A. Giaid, M. Yanagisawa, D. Langleben, R. Michel, R. Levy, H. Shennib, S. Kimura, Tomoh Masaki, William P. Duguid, D. Stewart   +9 more
semanticscholar   +1 more source

Bosentana no tratamento de úlceras de extremidades refratárias na esclerose sistêmica Bosentan in the treatment of refractory extremities ulcers in systemic sclerosis

Revista Brasileira de Reumatologia, 2009
INTRODUÇÃO: Acometimento vascular é uma manifestação central da esclerose sistêmica (ES) e pode levar a complicações como úlceras, gangrena ou amputação de extremidades.
Henrique de Ataíde Mariz, Marcelo José Uchôa Corrêa, Cristiane Kayser   +2 more
doaj   +1 more source

Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve? [PDF]

, 2012
In the early 1990s, within three years of cloning of endothelin receptors, orally active endothelin receptor antagonists (ERAs) were tested in humans and the first clinical trial of ERA therapy in humans was published in 1995.
Barton, Matthias, Cleland, John G., Kohan, Donald E., Rubin, Lewis J., Theodorescu, Dan   +4 more
core   +1 more source