Results 21 to 30 of about 90,498 (305)
Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats
Biology, 2023 The ubiquitous peptide endothelin is currently under investigation as a modulatory factor of autonomic responses to acute emotional stress. Baseline plasma levels of endothelin alter blood pressure responses, but it remains unclear whether autonomic ...
Eleni-Taxiarchia Mouchtouri +7 more
doaj +1 more source
Life Sciences, 2012 Following the initial description of endothelium-dependent vasoconstriction in the early 1980s, it has been exactly 25 years since efforts to identify the sequence of the endothelin gene and peptide began in May 1987, work which resulted in a landmark paper submitted to Nature in December 1987 and published on March 31, 1988.
Yanagisawa, M +3 more
openaire +4 more sources
Clinical and Experimental Hypertension, 2023 Objective Endothelial function may improve with enhanced external counterpulsation (EECP) or acupuncture. This study aimed to evaluate the feasibility of acupoint stimulation combined with EECP (acupoint-EECP) for endothelial cell function in patients ...
Meilan Lin +11 more
doaj +1 more source
Endothelial Dysfunction in Acute Hepatic Porphyrias
Diagnostics, 2022 Background Acute hepatic porphyrias (AHPs) are a group of rare diseases caused by dysfunctions in the pathway of heme biosynthesis. Although acute neurovisceral attacks are the most dramatic manifestations, patients are at risk of developing long-term ...
Andrea Ricci +8 more
doaj +1 more source
Life Sciences, 2014 Twenty-five years ago, a groundbreaking paper from Tsukuba University in Japan was published, identifying the sequence of the endothelin gene and peptide (Nature 332, 411-415, 1988). This work opened the way for the discovery of the endothelin receptors and the development of orally active endothelin receptor antagonists (ERAs). Today, ERAs are part of
Emoto, N +4 more
openaire +4 more sources
Novel Treatment Paradigms: Primary IgA Nephropathy
Kidney International ReportsIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Approximately 30% to 45% of patients progress to kidney failure (KF) within 20 to 25 years of diagnosis, and there has long been a lack of effective treatments.
Haresh Selvaskandan +2 more
doaj +1 more source
Медицинский вестник Юга России, 2015 Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.Materials and methods: 160 railroad ...
I. S. Lutskyy +4 more
doaj +1 more source
Indian Journal of Respiratory Care, 2022 Wilson's disease is one of the infrequent causes of hepatic failure with a wide clinical spectrum. Hepatic and neuropsychiatric manifestations are the most common, whereas atypical presentations were also reported as the complications of hepatic failure ...
V V. S. S. Sagar +5 more
doaj +1 more source
Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
EMBO Molecular Medicine, 2017 Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations ...
Michael P Smith +20 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source