Results 41 to 50 of about 90,498 (305)
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
New England Journal of Medicine, 1995 Based on the data from current literature a survey of the new endothelial cell derived peptides endothelins and their characteristics are given. Having the most and longest vasoconstrictor activity that has been described to date and ability to stimulate the release aldosterone, catecholamine and renin, endothelin-1 became the subject of many studies ...
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Кардиоваскулярная терапия и профилактика, 2007 Aim. To optimize chronic heart failure (CHF) pharmacotherapy, basing on endothelin (ET) system activity, functional and cardio-hemodynamic parameters, and their dynamics in beta-adrenoblocker nebivolol therapy. Material and methods. The study included 52
L. I. Olbinskaya, Yu. I. Naymann
doaj
DiseasesBackground: Diabetes mellitus (DM) is a global health challenge with a severe health burden. Approximately 40% of diabetic patients develop diabetic kidney disease (DKD), leading to kidney failure.
Ardianto Pramono +6 more
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Frontiers in Pharmacology, 2015 Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery.
Nicola J Smith, Nicola J Smith
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Role of prostanoids, nitric oxide and endothelin pathways in pulmonary hypertension due to COPD
Frontiers in Medicine, 2023 Pulmonary hypertension (PH) due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 PH, with no current proven targeted therapies. Studies suggest that cigarette smoke, the most risk factor for COPD can cause vascular remodelling and
Abdullah A. Alqarni +12 more
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NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Frontiers in Physiology, 2016 We studied the influence of pretreatment with endothelin 1 on cardiac baroreflexes and on the effect of clonidine on blood pressure and heart rate. In order to avoid the complication of the direct vasoconstrictor effects of endothelin-1, initial dose ...
Kyungjoon Lim +2 more
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Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury
Cells, 2023 Traumatic brain injury (TBI) is an intracranial injury caused by accidents, falls, or sports. The production of endothelins (ETs) is increased in the injured brain.
Shotaro Michinaga +2 more
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Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium [PDF]
Reproduction, 1993 This study determined the presence of specific endothelin isoforms in human endometrium using high performance liquid chromatography (HPLC) combined with radioimmunoassay, and immunocytochemistry to detect the endothelin precursors (proendothelin-1, proendothelin-2 and proendothelin-3).
I T, Cameron +5 more
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