Results 41 to 50 of about 208,585 (381)

Endothelin XIII

Life Sciences, 2014
Twenty-five years ago, a groundbreaking paper from Tsukuba University in Japan was published, identifying the sequence of the endothelin gene and peptide (Nature 332, 411-415, 1988). This work opened the way for the discovery of the endothelin receptors and the development of orally active endothelin receptor antagonists (ERAs). Today, ERAs are part of
Emoto, N, Masaki, T, Goto, K, Vanhoutte, PMGR, Yanagisawa, M   +4 more
openaire   +4 more sources

Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium [PDF]

Reproduction, 1993
This study determined the presence of specific endothelin isoforms in human endometrium using high performance liquid chromatography (HPLC) combined with radioimmunoassay, and immunocytochemistry to detect the endothelin precursors (proendothelin-1, proendothelin-2 and proendothelin-3).
Christopher Plumpton, I. T. Cameron, R. Champeney, C. van Papendorp, Michael J. Ashby, Anthony P. Davenport   +5 more
openaire   +3 more sources

THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS

Медицинский вестник Юга России, 2015
Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.Materials and methods: 160 railroad ...
I. S. Lutskyy, S. V. Ziablices, M. S. Kishenia, L. V. Liutykova, P. A. Chernobrivec   +4 more
doaj   +1 more source

Endothelin and the ischaemic heart [PDF]

, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
Kane, K.A., McCabe, C., Wainwright, C.L.
core   +1 more source

Hepatopulmonary syndrome and portopulmonary hypertension coexisting in a case of wilson's disease cirrhosis: “Double trouble”

Indian Journal of Respiratory Care, 2022
Wilson's disease is one of the infrequent causes of hepatic failure with a wide clinical spectrum. Hepatic and neuropsychiatric manifestations are the most common, whereas atypical presentations were also reported as the complications of hepatic failure ...
V V. S. S. Sagar, Sourya Acharya, Gajendra Agrawal, Samarth Shukla, Sunil Kumar, Chitturi Venkata Sai Akhil   +5 more
doaj   +1 more source

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]

, 2008
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A., Clerk, Angela, Cullingford, Timothy E., Dennis, Jayne L., Ekere, C., Fuller, Stephen John, Game, Laurence, Giraldo, Alejandro, Kemp, Timothy J., Markou, T., Pikkarainern, Sampsa, Sugden, Peter H., Zoumpoulidou, Georgia   +12 more
core   +2 more sources

Association of Elevated Plasma Endothelin-1 Levels With Pulmonary Hypertension, Mortality, and Heart Failure in African American Individuals: The Jackson Heart Study.

JAMA cardiology, 2016
IMPORTANCE Despite pathophysiological links between endothelin-1 and pulmonary vascular remodeling, to our knowledge, the association between plasma endothelin-1 levels and pulmonary hypertension has not been studied in the general population.
M. Jankowich, Wen‐Chih Wu, G. Choudhary   +2 more
semanticscholar   +1 more source

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Proceedings of the National Academy of Sciences of the United States of America, 1988
Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of the rat.
G. Nucci, R. Thomas, P. D'Orléans-Juste, E. Antunes, C. Walder, T. Warner, J. Vane   +6 more
semanticscholar   +1 more source

Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis

Frontiers in Immunology, 2020
Background: Activation of protease-activated receptor-2 (PAR2) has been implicated in inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis (AD), as well as Netherton syndrome which has similar characteristics ...
Timo Buhl, Timo Buhl, Akihiko Ikoma, Akihiko Ikoma, Cordula Kempkes, Ferda Cevikbas, Mathias Sulk, Mathias Sulk, Joerg Buddenkotte, Joerg Buddenkotte, Tasuku Akiyama, Tasuku Akiyama, Debbie Crumrine, Eric Camerer, Earl Carstens, Michael P. Schön, Peter Elias, Shaun R. Coughlin, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff   +24 more
doaj   +1 more source

Endothelial Dysfunction in Acute Hepatic Porphyrias

Diagnostics, 2022
Background Acute hepatic porphyrias (AHPs) are a group of rare diseases caused by dysfunctions in the pathway of heme biosynthesis. Although acute neurovisceral attacks are the most dramatic manifestations, patients are at risk of developing long-term ...
Andrea Ricci, Gilda Sandri, Matteo Marcacci, Elena Di Pierro, Francesca Granata, Chiara Cuoghi, Stefano Marchini, Antonello Pietrangelo, Paolo Ventura   +8 more
doaj   +1 more source