Results 151 to 160 of about 304,687 (378)

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Primary heart involvement (pHI) is a severe but often overlooked complication of systemic sclerosis (SSc), linked to heart failure, arrhythmias and mortality. In a study of 600 patients from the Italian SPRING‐SIR registry, 25% had ECG or echocardiographic signs of pHI at baseline, associated with older age, diffuse skin disease and intestinal symptoms.
Antonio Tonutti   +91 more
wiley   +1 more source

Acute and short-term effects of the nonpeptide endothelin-1 receptor antagonist bosentan in humans [PDF]

open access: yes, 2018
Summary: In recent years, evidence from various animal experiments has accumulated that emphasizes the role of endothelin-1 in the pathophysiology of several cardiovascular diseases, including congestive heart failure.
Bertel, Osmund   +2 more
core  

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

open access: yesThe FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert   +16 more
wiley   +1 more source

Endothelin Inhibition as a Biologic Target for Treating Hypertension [PDF]

open access: yes, 2017
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, thereby inducing vasoconstriction. Although plasma levels are not consistently elevated in hypertension, there is evidence that endothelin has an important
Brunner, Hans R.
core  

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing   +3 more
wiley   +1 more source

Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice

open access: yesClinical Cancer Research, 2015
Sun-jin Kim   +13 more
semanticscholar   +1 more source

Retrospective analysis of influences of sacubitril/valsartan in patients with diabetes with poorly controlled blood pressure in Japan

open access: yesJournal of Diabetes Investigation, EarlyView.
Sacubitoril/valsartan vs thiazide in patients with diabetes. ABSTRACT Aims Achieving optimal blood pressure control remains challenging, particularly for patients with diabetes. This post‐hoc study compared the efficacy and safety of switching to sacubitril/valsartan vs adding thiazide diuretics in this population.
Shun Ito   +19 more
wiley   +1 more source

Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet. [PDF]

open access: yesClin Pharmacol Ther, 2021
Gueneau de Mussy P   +8 more
europepmc   +1 more source

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