Results 91 to 100 of about 285,474 (314)

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Exacerbation of AIH in a patient with an AIH/systemic sclerosis overlap syndrome and pulmonary arterial hypertension treated with the endothelin-1 receptor antagonist sitaxentan [PDF]

, 2012
Reinhild Klein, E.L. Hintz, Gerd Staehler   +2 more
openalex   +1 more source

Impact of Early‐Line Systemic Therapies on Liver Function in Hepatocellular Carcinoma: Longitudinal Change of ALBI Score and Ammonia Level With and Without Anti‐VEGF Agents

Hepatology Research, EarlyView.
ABSTRACT Background and Aim Anti–vascular endothelial growth factor (VEGF) agents are widely used for hepatocellular carcinoma (HCC); inhibition of VEGF‐mediated liver regeneration may compromise hepatic reserve. We investigated the impact of anti‐VEGF therapy on liver function and risk factors for deterioration of albumin–bilirubin (ALBI) score during
Naoshi Nishida, Kazuomi Ueshima, Tomoko Aoki, Takuya Matsubara, Naoya Omaru, Natsuki Okai, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Yasunori Minami, Masatoshi Kudo   +11 more
wiley   +1 more source

In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ET_B receptor [PDF]

, 1996
Volker Breu, Martine Clozel, Kaspar F. Burri, Georges Hirth, Werner Neidhart, Henri Ramuz   +5 more
openalex   +1 more source

Resistance exercise breaks during prolonged sitting augment the blood flow response to a subsequent oral glucose load in sedentary adults

Experimental Physiology, EarlyView.
Abstract Sitting‐induced impairments in postprandial blood flow are an important link between sedentary behaviour and cardiometabolic disease risk. The objective of this work was to examine the effects of resistance exercise breaks (REB) performed every 30 min during an otherwise sedentary 3‐h period on the vasodilatory response to a subsequent oral ...
Emily M. Rogers, Nile F. Banks, Emma R. Trachta, Morgan S. Wolf, Alexander C. Berry, Anna E. Stanhewicz, Lucas J. Carr, Bethany Barone Gibbs, Nathaniel D. M. Jenkins   +8 more
wiley   +1 more source

Supplementary Figure 6 from Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice

, 2023
Sun‐Jin Kim, Ho Jeong Lee, Mark Seungwook Kim, Hyun Jin Choi, Junqin He, Qiuyu Wu, Kenneth Aldape, Jeffrey S. Weinberg, W.K. Alfred Yung, Charles A. Conrad, Robert R. Langley, François Lehembre, Urs Regenass, Isaiah J. Fidler   +13 more
openalex   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

The therapeutic role of exercise training during menopause for reducing vascular disease

Experimental Physiology, EarlyView.
Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing, Bert Bond, Kerrie L. Moreau, Jeff S. Coombes, Jenna L. Taylor   +4 more
wiley   +1 more source

Derivatives of an endothelin A receptor antagonist for PET imaging [PDF]

, 2011

openalex   +1 more source

Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage [PDF]

, 2022
Aurélie Cullier, Frédéric Cassé, Seng Manivong, Romain Contentin, Florence Legendre, Aracéli Garcia Ac, Pierré Sirois, Gaëlle Roullin, Xavier Banquy, Florina Moldovan, Lélia Bertoni, Fabrice Audigié, Philippe Galéra, Magali Demoor   +13 more
openalex   +1 more source