Results 91 to 100 of about 16,284 (266)

A Long-Term Survivor With Alveolar Capillary Dysplasia

JACC: Case Reports, 2020
A patient with alveolar capillary dysplasia has survived more than 56 months with medical therapy. Intrauterine exposure to metformin potentially modified the severity of disease.
Chandler E. Yost, BS, Angelica R. Putnam, MD, Megan K. Dishop, MD, Lynda O. Jorgensen, RN, Paul E. Wirkus, MD, Ronald W. Day, MD   +5 more
doaj  

The potential benefit of endothelin receptor antagonists' therapy in idiopathic pulmonary fibrosis: A meta-analysis of results from randomized controlled trials. [PDF]

Medicine (Baltimore), 2022
Li S, Pan YL, Xin W, Yan C.
europepmc   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan

Journal of Pharmacological Sciences, 2014
.: The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [125I]ET-1.
Ayaka Osano, Yoshinari Yokoyama, Hideki Hayashi, Kunihiko Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada   +7 more
doaj  

Endothelin Receptor Antagonists as a Potential Treatment of Diabetic Nephropathy: A Systematic Review. [PDF]

Cureus, 2021
Ahmad N, Veerapalli H, Lankala CR, Castaneda EE, Aziz A, Rockferry AG, Hamid P.   +6 more
europepmc   +1 more source

Cell Biology of Cancer Peritoneal Metastasis: Multiclonal Seeding and Peritoneal Tumor Microenvironment

Cancer Science, Volume 116, Issue 5, Page 1171-1180, May 2025.
We summarize recent findings on the cell biological aspects of peritoneal metastasis and potential therapeutic target molecules. We focus on the molecular mechanisms underlying cluster/spheroid formation in multiclonal peritoneal metastasis and cancer–stroma interactions within the peritoneal tumor microenvironment. ABSTRACT Peritoneal metastasis, also
Hideki Yamaguchi, Makoto Miyazaki
wiley   +1 more source

Effects of an Endothelin-A Receptor Antagonist in a Porcine Model of Pulmonary Injury Induced by Oxygen and Inhaled Nitric Oxide [PDF]

, 1999
William E. Truog, Jihan Youssef, Donald W. Thibeault, Ikechukwu I. Ekekezie   +3 more
openalex   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Approaches to therapy for pulmonary hypertension: Role of the endothelin receptor antagonist bosentan

Терапевтический архив, 2015
Pulmonary hypertension (PH) is a specific clinical group of severe and rare diseases with similar morphological, hemodynamic, and therapeutic characteristics. Despite the fact that there have been international conciliative documents and advances in drug
S N Avdeev
doaj