Results 131 to 140 of about 297,055 (354)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post   +4 more
wiley   +1 more source

Shared determinants of receptor binding for subtype selective, and dual endothelin‐angiotensin antagonists on the AT1 angiotensin II receptor [PDF]

open access: bronze, 1998
David Dascal   +5 more
openalex   +1 more source

The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease

open access: yesKidney Diseases, 2019
Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling ...
R. Raina   +6 more
semanticscholar   +1 more source

Asymmetric Synthesis of a Selective Endothelin A Receptor Antagonist.

open access: yesChemical and Pharmaceutical Bulletin, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Koji Tomimoto   +8 more
openaire   +5 more sources

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau   +20 more
wiley   +1 more source

Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan

open access: yesJournal of Pharmacological Sciences, 2014
.: The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [125I]ET-1.
Ayaka Osano   +7 more
doaj  

A Long-Term Survivor With Alveolar Capillary Dysplasia

open access: yesJACC: Case Reports, 2020
A patient with alveolar capillary dysplasia has survived more than 56 months with medical therapy. Intrauterine exposure to metformin potentially modified the severity of disease.
Chandler E. Yost, BS   +5 more
doaj  

Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review. [PDF]

open access: yesCureus, 2023
Nahar S   +9 more
europepmc   +1 more source

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