Results 131 to 140 of about 297,055 (354)
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post+4 more
wiley +1 more source
Shared determinants of receptor binding for subtype selective, and dual endothelin‐angiotensin antagonists on the AT1 angiotensin II receptor [PDF]
David Dascal+5 more
openalex +1 more source
The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease
Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling ...
R. Raina+6 more
semanticscholar +1 more source
Asymmetric Synthesis of a Selective Endothelin A Receptor Antagonist.
AbstractFor Abstract see ChemInform Abstract in Full Text.
Koji Tomimoto+8 more
openaire +5 more sources
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye+5 more
wiley +1 more source
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau+20 more
wiley +1 more source
Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan
.: The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [125I]ET-1.
Ayaka Osano+7 more
doaj
A Long-Term Survivor With Alveolar Capillary Dysplasia
A patient with alveolar capillary dysplasia has survived more than 56 months with medical therapy. Intrauterine exposure to metformin potentially modified the severity of disease.
Chandler E. Yost, BS+5 more
doaj
Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review. [PDF]
Nahar S+9 more
europepmc +1 more source
Hepatoprotective effect of the endothelin receptor antagonist TAK-044 against ischemia-reperfusion injury in the canine liver [PDF]
Yoshihiro Kitayama+4 more
openalex +1 more source