Results 101 to 110 of about 4,400 (309)

Methods to Evaluate the Effect of Ethanol on the Folate Analogue: Fluorescein Methotrexate Uptake in Human Proximal Tubular Cells

open access: yesAdvances in Pharmacological Sciences, 2009
Ethanol-induced folate deficiency is due to effects of ethanol on folate metabolism and absorption. We have already shown by using different methods that ethanol interferes with reabsorption of folate from the proximal tubule. In this study, we have used
Sivakumar JT Gowder, Kenneth E. McMartin
doaj   +1 more source

Comparison of plasma endothelin levels between osteoporotic, osteopenic and normal subjects

open access: yesBMC Musculoskeletal Disorders, 2005
Background It has been demonstrated that endothelins (ET) have significant roles in bone remodeling, metabolism and physiopathology of several bone diseases. We aimed to investigate if there was any difference between the plasma ET levels of osteoporotic
Biçimoğlu Ali   +3 more
doaj   +1 more source

Why two endothelins and two receptors for ovulation and luteal regulation?

open access: yes, 2012
The ovary is a dynamic organ that undergoes cyclic structural and functional changes. Structurally, the internal architecture of the ovary constantly changes as follicles grow, rupture and transform into corpora lutea in a cyclical manner.
Bridges, Phillip J.   +2 more
core   +1 more source

New research on endothelins and their receptors

open access: yes, 2015
Адрес за кореспонденция: Д-р Георги Асенов Богданов Катедра по фармакология и токсикология Медицински факултет Медицински университет, ул.
Методиев/Metodieva, Р./R.   +2 more
core  

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Children with congenital heart disease (CHD) frequently undergo cardiac magnetic resonance imaging (MRI) under anesthesia. Although these procedures lack surgical stimulus, patients remain physiologically vulnerable, and the incidence of perioperative cardiovascular instability in this setting is poorly defined.
Theodora Wingert   +8 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Changes of hemostasis, endogenous fibrinolysis, platelet activation and endothelins after percutaneous transluminal coronary angioplasty in patients with stable angina

open access: yes, 1999
OBJECTIVESThis study investigated parameters of endogenous fibrinolysis, activation of coagulation and platelets, and endothelin levels before and after elective percutaneous transluminal coronary angioplasty (PTCA) in patients with stable coronary ...
Schoebel, Frank C.   +8 more
core   +1 more source

The pathochemical role of endothelins in kidney diseases [PDF]

open access: yes, 2022
Introduction. Endothelin-1(ET-1) is an important regulator of kidney function in health and disease. ET-1, largely through activation of endothelin A receptors, has been strongly implicated in renal cell injury, proteinuria, inflammation and fibrosis ...
Rajan, Aravind, Sardari, Veronica
core  

Structural basis of antagonist selectivity in endothelin receptors

open access: yesCell Discovery
Endothelins and their receptors, ETA and ETB, play vital roles in maintaining vascular homeostasis. Therapeutically targeting endothelin receptors, particularly through ETA antagonists, has shown efficacy in treating pulmonary arterial hypertension (PAH)
Junyi Hou   +15 more
doaj   +1 more source

Intracerebroventricular Administration of an Endothelin ETB–Receptor Agonist Increases Expression of Matrix Metalloproteinase-2 and -9 in Rat Brain

open access: yesJournal of Pharmacological Sciences, 2010
.: Matrix metalloproteinases (MMPs), a family of zinc-endopeptidases, have a critical role in the pathophysiological responses in damaged brains. MMPs are up-regulated in brain pathologies.
Yutaka Koyama, Kazuhiro Tanaka
doaj   +1 more source

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