Results 271 to 280 of about 87,171 (374)

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song   +3 more
wiley   +1 more source

Reduction in Local Cerebral Blood Flow Induced by Endothelin-1 Applied Topically to the Middle Cerebral Artery in the Rat

open access: bronze, 1991
Michael J. Robinson   +4 more
openalex   +1 more source

Efficient Regioselective Iodination of Pyrazole Derivatives Mediated by Cadmium(II) Acetate

open access: yesChemistryOpen, Volume 14, Issue 7, July 2025.
The iodination reactions of both N, C alkyl‐, propargylic substituted and unsubstituted pyrazole derivatives initiated by cadmium (II) acetate were performed. It was revealed that the C‐4 position of the pyrazole ring was more nucleophilic. The nucleophilicity of the pyrazole ring significantly increased due to the influence of alkyl groups and ...
Nina G. Hobosyan   +8 more
wiley   +1 more source

Aprocitentan in hypertension management: clinical efficacy, safety, and future prospects. [PDF]

open access: yesAnn Med Surg (Lond)
Riaz R   +6 more
europepmc   +1 more source

A Patient With Pulmonary Hypertension Carrying FLNA Loss‐of‐Function Variant

open access: yesPulmonary Circulation, Volume 15, Issue 3, July 2025.
Abstract In a recent study conducted by Laura Stourm et al., the authors identified that patients with pulmonary hypertension (PH) harboring loss‐of‐function variants in the Filamin A (FLNA) gene exhibit a unique spectrum of phenotypes. These include pulmonary involvement with lung parenchymal abnormalities and emphysema, as well as a range of ...
Zongye Cai   +9 more
wiley   +1 more source

Pharmacology of endothelin.

open access: yesJapanese Journal of Pharmacology, 1990
openaire   +3 more sources

Home - About - Disclaimer - Privacy