Results 271 to 280 of about 82,115 (315)
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Endothelins

Journal of Veterinary Medicine Series A, 1992
SummaryThe endothelins (ET) represent a novel family of at least three isopeptides (ET‐1, ET‐2, ET‐3), each consisting of 21 amino acids and two disulfide bridges. ET has originally been isolated from the supernatant of porcine aortic endothelial cells and has been found to be the most potent and long lasting vasoconstrictor agent yet discovered. ET is
openaire   +2 more sources

Endothelins in chronic diabetic complications.

Canadian Journal of Physiology and Pharmacology, 2003
Endothelins are widely distributed in the body and perform several vascular and nonvascular functions. Experimental data indicate abnormalities of the endothelin system in several organs affected in chronic diabetic complications.
Z. Khan, S. Chakrabarti
semanticscholar   +1 more source

Ocular effects of the endothelins. Abundant peptides in the eye.

A M A Archives of Ophthalmology, 1991
Endothelins (ETs) are a family of potent vasoactive peptides present in the eye. In the rabbit eye, both ET-1 and ET-3 are present in high concentrations in the iris and ciliary body and in lower concentrations elsewhere.
M. MacCumber, H. Jampel, S. Snyder
semanticscholar   +1 more source

Endothelins and the lung

The International Journal of Biochemistry & Cell Biology, 2000
Since endothelins were discovered by Yanasigawa in 1988 it has been recognised that they may have an important role in lung pathophysiology. Despite their biological importance as vasoconstrictors the physiological role of endothelin has not yet been defined within the lungs. This review explores their role in acute and chronic disease.
Michael Boscoe   +3 more
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Endothelin and endothelin antagonists in hypertension

Journal of Hypertension, 1998
The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many different tissues, particularly in the endothelium of blood vessels. ET-1 is the main endothelin secreted by the endothelium, and acts in a paracrine or autocrine fashion on blood vessels by interacting with ETA or ETB receptors on smooth muscle to stimulate ...
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Regional extraction of endothelins and conversion of big endothelin to endothelin‐1 in the pig

Acta Physiologica Scandinavica, 1991
Endothelin‐like immunoreactivity (ET‐LI), mean arterial blood pressure (MABP) and vascular resistance in the spleen, kidney and femoral vascular bed were measured during intravenous infusions (20 pmol. kg‐1. min) of endothelin‐2 (ET‐2), endothelin‐3 (ET‐3), big endothelin‐1 (big ET) and sarafotoxin 6b in the pig.
Jan M. Lundberg   +2 more
openaire   +3 more sources

Endothelins and pulmonary diseases.

Journal of applied physiology, 1994
Endothelins (ETs) are expressed in several types of cell in human lung, including airway epithelial cells, pulmonary vascular endothelial cells, submucosal glands, and type II pneumocytes.
P. J. Barnes
semanticscholar   +1 more source

Development of a Photolabile Ligand for the Endothelin-A Receptor of Endothelin

Journal of Cardiovascular Pharmacology, 2000
Actions of endothelin (ET) are usually mediated through the so-called endothelin-A or -B (ET(A) or ET(B))-receptors. As part of our ongoing research program, we are studying the characterization of the ET(A)-receptor using specific photolabile ligands.
S Tessier   +5 more
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Endothelins as cardiovascular peptides.

American Journal of Nephrology, 1996
The normal functional state of the vasculature and the events leading to the development of significant arterial disease involve the interaction of important vasoactive substances, which play important modulating or initiating roles in the development of
Ellis R. Levin
semanticscholar   +1 more source

Endothelin in hypertension

Current Opinion in CARDIOLOGY, 1995
The endothelins, 21-amino-acid peptides produced by the endothelium of blood vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent vasoconstrictors, and are also endowed with mitogenic and cell hypertrophic properties.
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