Results 281 to 290 of about 4,400 (309)

Endothelin and Endothelin Receptor Antagonism in Heart Failure

Journal of Cardiovascular Pharmacology, 2000
Endothelin (ET)-1 is a potent vasoconstrictor with growth promoting and mitogenic properties associated with various cardiovascular diseases (CVD) and has been found to be an important protagonist in congestive heart failure (CHF). The introduction of ET-1 receptor antagonists into the arena of clinical research has amplified our understanding of the ...
Sütsch G, Kiowski W
openaire   +3 more sources

Endothelin, endothelin receptors, and endothelin antagonists.

Current opinion in nephrology and hypertension, 1995
Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor, ETC. In vascular smooth muscle cells, endothelin causes profound contraction and also has proliferative effects, mainly through activation of ETA but also through ETB ...
openaire   +1 more source

Endothelins and anti-endothelins.

The Journal of the Association of Physicians of India, 2001
Endothelins, endothelin-1 (ET1), endothelin-2 (ET2) and endothelin-3 (ET3), are the most potent vasoconstrictor peptides released by endothelial cells. ET production is stimulated by vasopressor hormones, platelet-derived factors, coagulation products and cytokines, whereas nitric oxide and prostacyclin reduce ET production.
openaire   +1 more source

Endothelin and Endothelin Antagonists: Pharmacology and Clinical Implications

1995
Endothelins (ET) are a family of peptides with potent biological properties. Endothelial cells produce exclusively ET-1 while other tissues produce ET-2 and ET-3. The production of ET requires an increase in intracellular Ca2+. This increase can be induced by physical chemicals (i.e. hypoxia) or receptor-operated stimuli (i.e. thrombin, angiotensin II,
Lüscher TF, Wenzel RR
openaire   +3 more sources

Endothelin and Endothelin Receptor Antagonists in Heart Failure

Congestive Heart Failure, 2002
Endothelin (ET) is a recently discovered 21‐amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These include effects on arterial smooth muscle cells that cause intense peripheral vasoconstriction and stimulation of cardiac myocytes and fibroblasts.
openaire   +2 more sources

Endothelin

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
openaire   +2 more sources

RADIOIMMUNOASSAY OF ENDOTHELIN

The Lancet, 1989
E, Hartter, W, Woloszczuk
openaire   +2 more sources

Endothelins and the Lung

American journal of respiratory and critical care medicine, 1996
J R, Michael, B A, Markewitz
openaire   +2 more sources

Growth regulatory properties of endothelins

Peptides, 1993
Pedro D'Orléans-Juste, Normand Briere, P Sirois   +2 more
exaly  

Endothelins in the control of cardiovascular and renal function

Lancet, The, 1993
Giuseppe Remuzzi, Ariela Benigni
exaly