Results 61 to 70 of about 37,353 (347)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Microvessel density in the placental bed among preeclampsia patients

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia, one of the largest causes of maternal and perinatal morbidity and mortality.
Tarcisio Mota Coelho, Nelson Sass, Luiz Camano, Antonio Fernandes Moron, Rosiane Mattar, João Noberto Stávale, Maria Regina Régis Silva, Marília da Glória Martins, João Nogueira Neto   +8 more
doaj   +1 more source

Anti-endothelin drugs in solid tumors [PDF]

, 2010
Importance of the field: The endothelin (ET) axis, which includes the biological functions of ETs and their receptors, has played a physiological role in normal tissue, acting as a modulator of vasomotor tone, tissue differentiation and development, cell
Bazan, V., Bronte, G., DI GAUDIO, F., Fanale, D., Gebbia, N., Rizzo, S., Russo, A.   +6 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Endothelin receptors promote schistosomiasis-induced hepatic fibrosis via splenic B cells.

PLoS Pathogens, 2020
Endothelin receptors (ETRs) are activated by vasoactive peptide endothelins and involved in the pathogenesis of hepatic fibrosis. However, less is known about the role of ETRs in Schistosoma (S.) japonicum-induced hepatic fibrosis. Here, we show that the
Hongyan Kong, Jinan He, Shusen Guo, Qiqin Song, Dandan Xiang, Ran Tao, Haijing Yu, Guang Chen, Zhiyong Huang, Qin Ning, Jiaquan Huang   +10 more
doaj   +1 more source

Análise dos níveis de endotelina-1 na saliva de pacientes portadores de carcinoma espinocelular bucal [PDF]

, 2010
Objectives: The present study aimed to verify if the salivary Endothelin-1 (ET-1) expression might represent an efficient biomarker to evaluate risk and prognosis from oral squamous cell carcinoma (OSCC).Methods: For the present study, saliva obtained ...
Hoffmann, Renata da Rocha
core  

The EVA spectral descriptor [PDF]

, 2000
The EVA descriptor is derived from fundamental IR- and Raman range molecular vibrational frequencies. EVA is sensitive to 3D structure but has an advantage over field-based 3D-QSAR methods inasmuch as it is invariant to both translation and rotation of ...
Turner, D.B., Willett, P.
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

HERVs, transposons and human diseases : part 3 [PDF]

, 2012
Part 1 and 2 of this article can be found through theses links: https://www.um.edu.mt/library/oar//handle/123456789/12961 https://www.um.edu.mt/library/oar//handle/123456789/13012Part 3 of the article.
Baldacchino, Sandra, Grech, Alfred
core   +1 more source

Endothelin-3 like immunoreactivity in plasma of patients with cirrhosis of the liver [PDF]

, 1992
A highly specific and sensitive radioimmunoassay (RIA) has been established for determination of endothelin-3 like immunoreactivity in human plasma to investigate its possible role in hemodynamic alterations due to liver disease.
Alexander L. Gerbes, Angelika M. Vollmar, De Gouville, Fukuda, Gerbes, Gerbes, Gerbes, Gustav Paumgartner, Inoue, Masaki, Matsumoto, Miyauchi, Miyauchi, Nayler, Randall, Samson, Suzuki, Veit Gülberg, Yanagisawa   +18 more
core   +1 more source