Results 201 to 210 of about 267,107 (334)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, EarlyView.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu   +17 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Global weak solutions to a fractional Cahn-Hilliard cross-diffusion system in lymphangiogenesis [PDF]

arXiv
A spectral-fractional Cahn-Hilliard cross-diffusion system, which describes the pre-patterning of lymphatic vessel morphology in collagen gels, is studied. The model consists of two higher-order quasilinear parabolic equations and describes the evolution of the fiber phase volume fraction and the solute concentration.
arxiv  

Short‐term and long‐term outcomes of self‐expandable metallic stent placement versus creation of a diverting stoma for obstructive colorectal cancer: A systematic review and meta‐analysis

Annals of Gastroenterological Surgery, EarlyView.
SEMS contributed to comparable outcomes including postoperative complications, mortality, and long‐term outcomes, but significantly reduced SSI. These findings support the broader adoption of SEMS in clinical practice, particularly requiring minimized invasiveness and improving patient quality of life are prioritized. Abstract Aim A diverting stoma (DS)
Thanakorn Yingruxpund, Akihisa Matsuda, Takeshi Yamada, Chaiya Chansai, Hiroshi Yoshida   +4 more
wiley   +1 more source

Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function.

JCI insight
The expression and functional relevance of the gap junction molecule connexin-45 (Cx45; GJC1) in lymphatic endothelium were not previously known. We found that Cx45 was expressed widely in the endothelium of murine lymphatics, in both valve and nonvalve regions.
Davis, Michael J., Castorena-Gonzalez, Jorge A., Li, Min, Zawieja, Scott D., Simon, Alex M., Geng, Xin, Srinivasan, R. Sathish   +6 more
openaire   +2 more sources

Does surgical intervention contribute to survival for patients with para‐aortic lymph node metastasis from colorectal cancer?

Annals of Gastroenterological Surgery, EarlyView.
Overall survival of patients who underwent surgical resection was significantly better compared to that of patients who underwent chemotherapy without surgical resection. These results highlight the benefit of surgical intervention to survival for patients with isolated para‐aortic lymph node metastasis or with resectable liver metastasis.
Akira Ouchi, Koji Komori, Sono Ito, Yusuke Kinugasa, Soichiro Ishihara, Akio Shiomi, Yukihide Kanemitsu, Takeshi Suto, Hiroki Takahashi, Yoichi Ajioka, on behalf of the study group for PALNM projected by JSCCR, Akinobu Furutani, Akira Hirata, Atsushi Ishibe, Eiji Sunami, Heita Ozawa, Hideki Ueno, Hideyuki Ishida, Hiroyuki Egi, Ichiro Takemasa, Jun Watanabe, Junichiro Hiro, Kay Uehara, Kazushige Kawai, Koya Hida, Manabu Shiozawa, Masaaki Ito, Masakatsu Numata, Masanori Hotchi, Masaya Hiyoshi, Masayuki Ohue, Michio Itabashi, Ryo Inada, Shuntaro Nagai, Takaya Kobatake, Takeshi Kato, Tomohiro Yamaguchi, Yasumasa Takii, Yasumitsu Hirano, Yoshihiro Kakeji   +39 more
wiley   +1 more source

MLV$^2$-Net: Rater-Based Majority-Label Voting for Consistent Meningeal Lymphatic Vessel Segmentation [PDF]

arXiv
Meningeal lymphatic vessels (MLVs) are responsible for the drainage of waste products from the human brain. An impairment in their functionality has been associated with aging as well as brain disorders like multiple sclerosis and Alzheimer's disease. However, MLVs have only recently been described for the first time in magnetic resonance imaging (MRI),
arxiv  

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes

Arteriosclerosis, Thrombosis and Vascular Biology, 2017
R. Bianchi, Erica Russo, Samia B. Bachmann, Steven T. Proulx, Marko Sesartić, Nora Smaadahl, S. Watson, C. Buckley, C. Halin, M. Detmar   +9 more
semanticscholar   +1 more source

New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

, 2016
The lymphatic system serves a critical role in fluid homeostasis, lipid metabolism and immune surveillance. The growing appreciation of its implication in various diseases challenges the conventional view of lymphatics as a passive transport system.
openaire   +2 more sources