Results 231 to 240 of about 272,678 (276)

Real‐world efficacy and toxicity of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma according to IMDC risk criteria—A multi‐center retrospective analysis on behalf of the GUARDIANS group

open access: yesInternational Journal of Cancer, EarlyView.
What's New? The combination of ipilimumab and nivolumab as a first‐line treatment for advanced renal cell carcinoma has demonstrated durable response and tolerability in clinical trials. However, inclusion criteria for clinical studies are restrictive, and patients in the real‐world setting tend to have more comorbidities.
Hendrik Dinkel   +21 more
wiley   +1 more source

Causes and risk factors for death in infants with congenital chylothorax. [PDF]

open access: yesFront Pediatr
Kubo Y   +6 more
europepmc   +1 more source

Surgical site infections and sepsis in gynecological surgery

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Despite advancements in infection control, surgical site infections (SSIs) and postoperative sepsis remain significant challenges in gynecological surgery, contributing to increased morbidity, mortality, and healthcare costs. In low‐income countries, circulatory failure due to septic shock leads to most deaths after surgery, with sepsis ...
Cristina Taliento   +13 more
wiley   +1 more source

Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin. [PDF]

open access: yesSci Rep
Keenan TF   +11 more
europepmc   +1 more source

Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis

open access: yesiMetaMed, EarlyView.
Integrative analysis of LC‐PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung cancer complicated by tuberculosis. ABSTRACT Coexisting lung cancer and pulmonary tuberculosis (LC‐PTB) is clinically challenging in diagnosis and ...
Ling Yang   +10 more
wiley   +1 more source

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation

open access: yesiMetaOmics, EarlyView.
Microbiota‐gut‐brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood‐brain barrier (BBB), and brain. This integrated platform incorporates neural (blue), endocrine (yellow), immune (pink), and metabolic (green) pathways to investigate the impact ...
Yue Tang   +9 more
wiley   +1 more source

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

open access: yesInterdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou   +10 more
wiley   +1 more source

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