Results 41 to 50 of about 272,678 (276)

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

bioRxiv, 2019
Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood.
Eric Engelbrecht, Michel V. Lévesque, Liqun He, Michael Vanlandewijck, A. Nitzsche, Andrew Kuo, Sasha A. Singh, M. Aikawa, K. Holton, R. Proia, M. Kono, W. Pu, E. Camerer, C. Betsholtz, T. Hla   +14 more
semanticscholar   +1 more source

Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.

Frontiers in Immunology, 2013
Tissue drains fluid and macromolecules through lymphatic vessels, which are lined by a specialized endothelium that expresses peculiar differentiation proteins, not found in blood vessels (i.e: LYVE-1, Podoplanin, PROX-1 and VEGFR-3).
Ignacio eMelero, Alvaro eTeijeira, Ana eRouzaut   +2 more
doaj   +1 more source

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes

Frontiers in Microbiology, 2012
Kaposi’s Sarcoma is a highly vascularized tumor supporting large amounts of neo-angiogenesis. The major cell type in KS tumors is the spindle cell, a cell that expresses markers of lymphatic endothelium. KSHV, the etiologic agent of KS, is found in the
Terri A. DiMiao, Michael eLagunoff
doaj   +1 more source

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma [PDF]

, 2016
Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in ...
Huhtala, Heini, Laranne, Jussi, Lemstrom, Karl, Paavonen, Timo, Pohjola, Konsta, Rautiainen, Markus, Renkonen, Risto, Seppälä, Miia, Toppila-Salmi, Sanna   +8 more
core   +1 more source

PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration

Nature Communications, 2022
The Programmed death-1 (PD-1) and its ligand PD-L1 are critical checkpoints in the regulation of immune responses. Here the authors implicate PD-L1 signalling at lymphatic endothelium in the regulation of transendothelial migration of T cells.
Wenji Piao, Lushen Li, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Yigang Zhang, Isadora Tadeval Lape, Christina Paluskievicz, Keli L. Hippen, Young Lee, Emma Silverman, Marina W. Shirkey, Leonardo V. Riella, Bruce R. Blazar, Jonathan S. Bromberg   +14 more
doaj   +1 more source

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.

JCI Insight, 2017
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of ...
Florence Tatin, Edith Renaud-Gabardos, Anne-Claire Godet, Fransky Hantelys, F. Pujol, F. Morfoisse, D. Calise, Fanny Viars, P. Valet, B. Masri, A. Prats, B. Garmy-Susini   +11 more
semanticscholar   +1 more source

Assessment of pulmonary edema: principles and practice [PDF]

, 2018
Pulmonary edema increasingly is recognized as a perioperative complication affecting outcome. Several risk factors have been identified, including those of cardiogenic origin, such as heart failure or excessive fluid administration, and those related to ...
Assaad, Sherif, Friedman, Malcolm B., Kratzert, Wolf B., Perrino, Albert, Shelley, Benjamin   +4 more
core   +1 more source

Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium

Microcirculation, 2018
Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects
Yang Lee, Sanjukta Chakraborty, C. Meininger, M. Muthuchamy   +3 more
semanticscholar   +1 more source

Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Nature Communications, 2021
Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2+ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing ...
Dali Zhang, Junlan Huang, Xianding Sun, Hangang Chen, Shuo Huang, Jing Yang, Xiaolan Du, Qiaoyan Tan, Fengtao Luo, Ruobin Zhang, Siru Zhou, Wanling Jiang, Zhenhong Ni, Zuqiang Wang, Min Jin, Meng Xu, Fangfang Li, Liang Chen, Mi Liu, Nan Su, Xiaoqing Luo, Liangjun Yin, Ying Zhu, Jerry Q. Feng, Di Chen, Huabing Qi, Lin Chen, Yangli Xie   +27 more
doaj   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source