Results 21 to 30 of about 206,616 (264)
Molecular Therapy: Nucleic Acids, 2016 The regulation of function of endothelial cell–cell junctions is fundamental in sustaining vascular integrity. The polycistronic microRNA (miR) complexes containing miR-23a-27a-24-2, and 23b-27b-24-1 are predicted to target the majority of major ...
Jia Li +6 more
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Cross-Talk of NADPH Oxidases and Inflammation in Obesity
Antioxidants, 2023 Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity.
Henning Morawietz +6 more
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Vascular endothelium in diabetes [PDF]
American Journal of Physiology-Renal Physiology, 2017 Three decades ago a revolutionary idea was born that ascribed to dysfunctional endothelia some manifestations of diabetes, the Steno hypothesis, so named after the Steno Diabetes Center, Gentofte, in Denmark. Here I briefly outline the accomplishments accrued in the past 15 years to buttress this hypothesis.
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Redox Biology, 2017 Tobacco smoking and hemodynamic forces are key stimuli in the development of endothelial dysfunction and atherosclerosis. High laminar flow has an atheroprotective effect on the endothelium and leads to a reduced response of endothelial cells to ...
Sindy Giebe +6 more
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Extracellular matrix and nitric oxide based functional coatings for vascular stents
Engineered Regeneration, 2022 Cardiovascular diseases cause huge morbidity and mortality worldwide. Recently, vascular stents have been most frequently used to treat cardiovascular diseases thanks to their effectiveness at dilating blood vessels and maintaining the circulation of ...
Quhan Cheng +5 more
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Impaired endothelial function in lone atrial fibrillation [PDF]
Vojnosanitetski Pregled, 2013 Background/Aim. Impaired endothelial function has been previously documented in patients with atrial fibrillation (AF) and underlying comorbidities or older patients with idiopathic AF.
Polovina Marija +4 more
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Contributions of the Endothelium to Vascular Calcification [PDF]
Frontiers in Cell and Developmental Biology, 2021 Vascular calcification (VC) increases morbidity and mortality and constitutes a significant obstacle during percutaneous interventions and surgeries. On a cellular and molecular level, VC is a highly regulated process that involves abnormal cell transitions and osteogenic differentiation, re-purposing of signaling pathways normally used in bone, and ...
Li Zhang +5 more
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Anales de la Facultad de Medicina, 2014 Over the last 40 years, research on the vascular endothelium has provided important clues for the understanding of vascular disease. This new knowledge is finding its way into clinical medicine.
Salvador Moncada
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Journal of Pharmacological Sciences, 2011 .: Endothelium regulates vascular tone via release of endothelium-derived relaxing factors (EDRF) including nitric oxide (NO), prostaglandin I2 (PGI2), and endothelium-derived hyperpolarizing factor (EDHF).
Xin Jin +6 more
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Endothelium-Derived Relaxing Factor–Mediated Vasodilation in Mouse Mesenteric Vascular Beds
Journal of Pharmacological Sciences, 2012 The endothelium in rat mesenteric vascular beds has been demonstrated to regulate vascular tone by releasing mainly endothelium-derived hyperpolarizing factor (EDHF), which is involved in the activation of K+ channels and gap-junctions.
Hiroki Fujiwara +7 more
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