Results 31 to 40 of about 711,120 (258)

Contribution of Oxidative Stress to Endothelial Dysfunction in Hypertension

Frontiers in Physiology, 2012
Endothelial dysfunction is the hallmark of hypertension, which is a multifactorial disorder. In the cardiovascular system reactive oxygen species play a pivotal role in controlling the endothelial function and vascular tone.
Bruno Rodrigues Silva, Laena ePernomian, Lusiane Maria Bendhack   +2 more
doaj   +1 more source

Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure

Toxics, 2022
As the single cell lining of the heart and all blood vessels, the vascular endothelium serves a critical role in maintaining homeostasis via control of vascular tone, immune cell recruitment, and macromolecular transit.
Guru Prasad Sharma, Heather A. Himburg
doaj   +1 more source

Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice

, 2012
Aims: to determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.Methods: female C57BL6J mice were fed an obesogenic high fat diet (HF, 45%
Geraldine F Clough, Clough, G.F., Torrens Christopher, Mann, Giovanni E.; id_orcid, Hanson Mark A., Mann Giovanni E., Kimberley D Bruce, Cagampang Felino R. A., Christopher Torrens (114420), Mann, G.E., Ethirajan Priya, Richard C M Siow, Geraldine F. Clough (114433), Byrne Christopher D., Christopher D. Byrne (114429), Siow, Richard C. M.; id_orcid, Felino R. A. Cagampang (114423), Ethirajan, Priya, Cagampang, Felino R. A., Mark A. Hanson (114427), Bruce, K.D., Byrne, Christopher D., Richard C. M. Siow (114425), Giovanni E. Mann (114431), Priya Ethirajan, Mark A Hanson, Kimberley D. Bruce (114422), Bruce Kimberley D., Siow Richard C. M., Christopher D Byrne, Ethirajan, P., Priya Ethirajan (114421), Clough Geraldine F., Torrens, Christopher, Felino R A Cagampang, Giovanni E Mann, Hanson, Mark A., Christopher Torrens, Bruce, Kimberley D., Clough, Geraldine F., Siow, R.C., Cagampang, F.R.   +41 more
core   +1 more source

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney [PDF]

, 1993
Using isolated rat kidneys perfused at controlled pressure, we examined a potential role of endothelium-derived relaxing factor (EDRF) in the pressure control of renin secretion.
Kurtz, Armin, Scholz, H., A Kurtz, Armin Kurtz, Holger Scholz, H Scholz   +5 more
core   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P., Bourdoulous, S., Pierre-Olivier Couraud, John Greenwood, Leveque, M., Greenwood, J., Mathilde Leveque, Rampon, C., Couraud, P.-O., Jean-Pierre Couty, Christine Rampon, Marie-Pierre Laran-Chich, Couty, J.-P., Sandrine Bourdoulous   +13 more
core   +1 more source

Hydrogen Peroxide Is an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans

Journal of Pharmacological Sciences, 2003
Vascular endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide (NO), and a yet unidentified endothelium-derived hyperpolarizing factor (EDHF).
Matoba Tetsuya, Hiroaki Shimokawa
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

ENDOTHELIUM-DEPENDENT VASCULAR REACTIVITY IN DIABETES MELLITUS TYPE 2

Клиническая практика, 2017
The review presents modern information on the development of disorders of endothelium-dependent vascular reactivity in diabetes mellitus (DM) type 2. In type 2 DM, disorders of endothelium-dependent vascular reactivity associated with hyperglycemia and ...
K Yu Nikolaev, S S Bairamova, O V Tsygankova, G I Lyfshits   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [PDF]

, 2010
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension
Handschin, C, Heinrich, Kathrin, Schäfer, N, Heinrich, K, Winnik, Stephan, Matter, Christian M., Brokopp, Chad E., Tanner, F C, Tanner, Felix C., Landmesser, Ulf, Breitenstein, A, Handschin, Christoph, Stein, Sokrates, Landmesser, U, Lüscher, Thomas F., Breitenstein, Alexander, Schäfer, Nicola, Besler, C, Winnik, S, Lohmann, C, Lüscher, T F, Lohmann, Christine, Besler, Christian, Matter, C M, Brokopp, C E, Stein, S   +25 more
core   +1 more source