Results 61 to 70 of about 206,616 (264)

Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities

Frontiers in Pediatrics, 2019
Neonatal sepsis remains a major health issue worldwide, especially for low-birth weight and premature infants, with a high risk of death and devastating sequelae.
Carlo Pietrasanta, Carlo Pietrasanta, Carlo Pietrasanta, Lorenza Pugni, Andrea Ronchi, Ilaria Bottino, Beatrice Ghirardi, Guzman Sanchez-Schmitz, Guzman Sanchez-Schmitz, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Fabio Mosca, Fabio Mosca, Ofer Levy, Ofer Levy, Ofer Levy   +18 more
doaj   +1 more source

Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium

Physiological Reports, 2021
The health benefits of the natural polyphenol trans‐resveratrol may play an important role in preventing a variety of diseases. Resveratrol has been shown to reduce blood pressure and improve metabolic diseases such as type 2 diabetes mellitus and ...
Ian R. VanAntwerp, Laura E. Phelps, Jacob D. Peuler, Phillip G. Kopf   +3 more
doaj   +1 more source

Mechanosensing by Vascular Endothelium

Annual Review of Physiology
Mechanical forces influence different cell types in our bodies. Among the earliest forces experienced in mammals is blood movement in the vascular system. Blood flow starts at the embryonic stage and ceases when the heart stops. Blood flow exposes endothelial cells (ECs) that line all blood vessels to hemodynamic forces.
Xin Rui, Lim, Osama F, Harraz
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
doaj   +1 more source

Optogenetic intervention to the vascular endothelium [PDF]

Vascular Pharmacology, 2015
Endothelium lining the interior of cardiovascular system and most visceral organs plays an important role in vascular function. Its dysfunction occurs in some of the most challenging diseases. An important function of the endothelium is to release vasoactive substances that act on the smooth muscle to change vascular tones.
Shuang, Zhang, Ningren, Cui, Yang, Wu, Weiwei, Zhong, Christopher M, Johnson, Chun, Jiang   +5 more
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Vascular dysfunction contributes to postoperative organ injury. Exposure to high concentrations of oxygen during surgery is common and may impair vascular function.
Marcos G. Lopez, Arvind K. Pandey, Cassandra Hennessy, Christopher G. Hughes, Tarek S. Absi, Ashish S. Shah, Matthew S. Shotwell, David G. Harrison, Frederic T. Billings   +8 more
doaj   +1 more source

Reproducibility and validity of a novel invasive method of assessing peripheral microvascular vasomotor function.

PLoS ONE, 2019
In healthy arteries, blood flow is regulated by microvascular tone assessed by changes in blood flow volume and vascular resistance to endothelium-dependent and -independent vasodilators.
Scott Kinlay, Mariah Bundy, Melissa Chin, Desiree Tobin, Margot Quinn, Jacquelyn-My Do, Shannon Johnson, Sara Temiyasathit, Samantha Ly   +8 more
doaj   +1 more source

Microcirculatory disorders in scleroderma systematica: an association with vascular wall stiffness

Научно-практическая ревматология, 2013
Objective: to study the specific features of regulation of peripheral vascular tone and their association with the endothelial structure and function of large vessels in patients with scleroderma systematica (SDS). Subjects and methods. The investigation
Ulyana Yuryevna Ruzhentsova
doaj   +1 more source