Results 81 to 90 of about 231,849 (311)

Microcirculatory disorders in scleroderma systematica: an association with vascular wall stiffness

Научно-практическая ревматология, 2013
Objective: to study the specific features of regulation of peripheral vascular tone and their association with the endothelial structure and function of large vessels in patients with scleroderma systematica (SDS). Subjects and methods. The investigation
Ulyana Yuryevna Ruzhentsova
doaj   +1 more source

Effects of trans‐ versus cis‐resveratrol on adrenergic contractions of the rat tail artery and role of endothelium

Physiological Reports, 2021
The health benefits of the natural polyphenol trans‐resveratrol may play an important role in preventing a variety of diseases. Resveratrol has been shown to reduce blood pressure and improve metabolic diseases such as type 2 diabetes mellitus and ...
Ian R. VanAntwerp, Laura E. Phelps, Jacob D. Peuler, Phillip G. Kopf   +3 more
doaj   +1 more source

Optogenetic intervention to the vascular endothelium [PDF]

Vascular Pharmacology, 2015
Endothelium lining the interior of cardiovascular system and most visceral organs plays an important role in vascular function. Its dysfunction occurs in some of the most challenging diseases. An important function of the endothelium is to release vasoactive substances that act on the smooth muscle to change vascular tones.
Shuang, Zhang, Ningren, Cui, Yang, Wu, Weiwei, Zhong, Christopher M, Johnson, Chun, Jiang   +5 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR [PDF]

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: 2011/04619-0Processo FAPESP: 2011/19859-6Processo FAPESP: 2011/20998-0Processo FAPESP: 2012/01733-9This study has evaluated how the vascular endothelium of hypertensive rats ...
Perassa, Ligia A., Troiano, Jéssica A. [UNESP], Bendhack, Lusiane M., Pereira, Ariana A.F., Sumida, Doris H., Lima, Mariana S. [UNESP], Potje, Simone R., Sumida, Doris H. [UNESP], Lima, Mariana S., Nakamune, Ana Cláudia de Melo Stevanato [UNESP], Potje, Simone R. [UNESP], Antoniali, Cristina [UNESP], Vale, Gabriel T., Nakamune, Ana Cláudia de Melo Stevanato, Pereira, Ariana A.F. [UNESP], Antoniali, Cristina, Graton, Murilo E., Perassa, Ligia A. [UNESP], Tirapelli, Carlos R., Graton, Murilo E. [UNESP], Troiano, Jéssica A.   +20 more
core   +1 more source

Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Vascular dysfunction contributes to postoperative organ injury. Exposure to high concentrations of oxygen during surgery is common and may impair vascular function.
Marcos G. Lopez, Arvind K. Pandey, Cassandra Hennessy, Christopher G. Hughes, Tarek S. Absi, Ashish S. Shah, Matthew S. Shotwell, David G. Harrison, Frederic T. Billings   +8 more
doaj   +1 more source

Reproducibility and validity of a novel invasive method of assessing peripheral microvascular vasomotor function.

PLoS ONE, 2019
In healthy arteries, blood flow is regulated by microvascular tone assessed by changes in blood flow volume and vascular resistance to endothelium-dependent and -independent vasodilators.
Scott Kinlay, Mariah Bundy, Melissa Chin, Desiree Tobin, Margot Quinn, Jacquelyn-My Do, Shannon Johnson, Sara Temiyasathit, Samantha Ly   +8 more
doaj   +1 more source

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation

Cells, 2020
Clinical studies have established a connection between oxidative stress, aging, and atherogenesis. These factors contribute to senescence and inflammation in the endothelium and significant reductions in endothelium-dependent vasoreactivity in aged ...
Ellen E. Salmon, Jason J. Breithaupt, George A. Truskey   +2 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus [PDF]

, 2005
Michio Otsuki, Kayoko Goya, Soji KasayamaDepartment of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, JapanAbstract: Diabetes mellitus is an important risk factor for cardiovascular morbidity and mortality.
Michio Otsuki, Soji Kasayama, Kayoko Goya   +2 more
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