Results 71 to 80 of about 231,849 (311)

Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds

Journal of Pharmacological Sciences, 2009
We previously reported that endothelium-derived hyperpolarizing factor (EDHF)– mediated response time-dependently suppressed methoxamine-induced vasoconstriction in mesenteric vascular beds isolated from 8-week-old rats.
Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki   +8 more
doaj   +1 more source

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice. [PDF]

PLoS ONE, 2016
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining ...
Pierre J Guihard, Jiayi Yao, Ana M Blazquez-Medela, Luisa Iruela-Arispe, Kristina I Boström, Yucheng Yao   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hypothesis: ‘Vasocrine’ signalling from perivascular fat - a mechanism linking insulin resistance and vascular disease [PDF]

, 2005
Adipose tissue expresses cytokines which inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation to insulin. We propose a vasoregulatory role for local deposits of fat around the
Stehouwer, C.D.A., Eringa, E., Eringa, Etto, Stehouwer, C.D.A.; id_orcid, Eringa, E.C., Stehouwer, Coen D.A., Yudkin, J.S., Yudkin, John S.   +7 more
core   +1 more source

Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities

Frontiers in Pediatrics, 2019
Neonatal sepsis remains a major health issue worldwide, especially for low-birth weight and premature infants, with a high risk of death and devastating sequelae.
Carlo Pietrasanta, Carlo Pietrasanta, Carlo Pietrasanta, Lorenza Pugni, Andrea Ronchi, Ilaria Bottino, Beatrice Ghirardi, Guzman Sanchez-Schmitz, Guzman Sanchez-Schmitz, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Fabio Mosca, Fabio Mosca, Ofer Levy, Ofer Levy, Ofer Levy   +18 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]

, 2009
Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D., Jacob George, George, Jacob   +2 more
core   +1 more source

Mechanosensing by Vascular Endothelium

Annual Review of Physiology
Mechanical forces influence different cell types in our bodies. Among the earliest forces experienced in mammals is blood movement in the vascular system. Blood flow starts at the embryonic stage and ceases when the heart stops. Blood flow exposes endothelial cells (ECs) that line all blood vessels to hemodynamic forces.
Xin Rui, Lim, Osama F, Harraz
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism [PDF]

, 2009
The average UK adult consumes less than three portions of fruit and vegetables daily, despite evidence to suggest that consuming five portions daily could help prevent chronic diseases. It is recommended that fruit juice should only count as one of these
Niwat, Chutamat, George, Trevor, George, Trevor W, Gordon, Michael, Lovegrove, Julie A, Niwat, C., Gordon, Michael H, Waroonphan, S., Waroonphan, Saran, Lovegrove, Julie, George, T. W., Lovegrove, J. A., Gordon, M. H.   +12 more
core   +1 more source