Results 41 to 50 of about 465,276 (277)

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Alemany, Alewijnse, Alexander, Ancellin, Blazquez, Chun, Coussin, Felder, French, Galve-Roperh, Giuliano, Grainger, Hajrasouliha, Hemmings, Hemmings, Herradon, Ho, Ho, Howlett, Igarashi, Igarashi, Ikeda, Jarai, Kobayashi, Long, Melendez, Mukhopadhyay, Mulvany, Nofer, O'Sullivan, Offertaler, Oka, Paugh, Peters, Pitson, Pratt, Pyne, Pyne, Romano, Roviezzo, Sanchez, Sarkar, Smart, Sukocheva, Taha, Venkataraman, White, Zygmunt   +47 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Nano-scale architecture of blood-brain barrier tight-junctions

eLife, 2021
Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases.
Esther Sasson, Shira Anzi, Batia Bell, Oren Yakovian, Meshi Zorsky, Urban Deutsch, Britta Engelhardt, Eilon Sherman, Gad Vatine, Ron Dzikowski, Ayal Ben-Zvi   +10 more
doaj   +1 more source

Endothelium-related and neuro-mediated mechanisms of emphysema development in chronic obstructive pulmonary disease [PDF]

Терапевтический архив, 2020
Emphysema is one of the main manifestations of chronic obstructive pulmonary disease (COPD), and smoking is one of the most significant risk factors. The results of studies in humans and animals show the vascular endothelium initiates and modulates the ...
T. A. Brodskaya, V. A. Nevzorova, M. S. Vasileva, V. V. Lavrenyuk   +3 more
doaj   +1 more source

Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation [PDF]

, 2004
Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified.
Barger, Mark, Boegehold, Matthew A., Castranova, Vincent, Nurkiewicz, Timothy R., Porter, Dale W.   +4 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Vascular Function of Resistance Arteries Depends on NADPH Oxidase 4 and Is Exacerbated by Perivascular Adipose Tissue

Antioxidants
The NADPH oxidase NOX4 that releases H2O2 can mediate vasoprotective mechanisms under pathophysiological conditions in conductive arteries. However, the role of NOX4 in resistance arteries and in perivascular adipose tissue is not well understood.
Patrick Diaba-Nuhoho, Jennifer Mittag, Coy Brunssen, Henning Morawietz, Heike Brendel   +4 more
doaj   +1 more source

Murine Lewis Lung Carcinoma-Derived Endothelium Expresses Markers of Endothelial Activation and Requires Tumor-Specific Extracellular Matrix In Vitro

Neoplasia: An International Journal for Oncology Research, 2003
The purpose of the study was to identify characteristics specific to tumor-derived endothelium that may be important in tumor biology, or for the development of targeted therapeutics or imaging agents.
Jennifer R. Allport, Ralph Weissleder
doaj   +1 more source

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source