Results 31 to 40 of about 459,427 (295)

Diagnosis and management of iridocorneal endothelial syndrome [PDF]

, 2015
The iridocorneal endothelial (ICE) syndrome is a rare ocular disorder that includes a group of conditions characterized by structural and proliferative abnormalities of the corneal endothelium, the anterior chamber angle, and the iris.
Ambrosio, Oriella, Macchi, Ilaria, Mantelli, Flavio, Marenco, Marco, Rama, Paolo, SACCHETTI, MARTA   +5 more
core   +2 more sources

3-MA Inhibits Autophagy and Favors Long-Term Integration of Grafted Gad67–GFP GABAergic Precursors in the Developing Neocortex by Preventing Apoptosis

Cell Transplantation, 2014
In human neonates, immature GABAergic interneurons are markedly affected by an excitotoxic insult. While in adults the interest of cell transplantation has been demonstrated in several neurological disorders, few data are available regarding the immature
Christian Roux, Céline Lesueur, Caroline Aligny, Carole Brasse-Lagnel, Damien Genty, Stéphane Marret, Annie Laquerrière, Soumeya Bekri, Bruno J. Gonzalez   +8 more
doaj   +1 more source

Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. [PDF]

, 2018
We have systematically investigated how vascular smooth muscle α1 -adrenoceptor activation impacts endothelium-mediated vasodilation in isolated, myogenically active, rat cremaster muscle 1A arteries.
Braun, Andrew P, Davis, Michael J, Hill, Michael A, Mishra, Ramesh C, Rahman, Mohammad M, Wulff, Heike   +5 more
core   +1 more source

Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]

, 2019
Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus, Buttgereit, Frank, Duda, Georg N., Fiedler, Alexander F., Gaber, Timo, Hauser, Anja E., Köhler, Markus, Lang, Annemarie, Niesner, Raluca A., Rauch, Ariana, Schmidt-Bleek, Katharina, Stefanowski, Jonathan   +11 more
core   +1 more source

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1-CD44 axis. [PDF]

, 2020
The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftment ...
Aggoune, D., Godavarthy, P., Hayduk, N., Herkt, S., Krause, D., Kumar, R., Lausen, J., Lucas, T., Manavski, Y., Müller, M., Oehler, V., Oellerich, T., Pan, K., Pereira, R., Saussele, S., Voutsinas, J., Weissenberger, E., Wu, Q.   +17 more
core   +2 more sources

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin, Kunuthur, S. P., Milliken, P. H., Suckling, C. J., Wadsworth, R. M.   +4 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]

, 2013
Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I, Morten Andre Høydal, Ole Johan Kemi, Per Magnus Haram, Ulrik Wisløff, Øyvind Ellingsen   +5 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy

Nature Communications
Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the intra-tumoral diversity of CAFs in basal cell carcinoma, squamous cell carcinoma, and melanoma using molecular and spatial single ...
Agnes Forsthuber, Bertram Aschenbrenner, Ana Korosec, Tina Jacob, Karl Annusver, Natalia Krajic, Daria Kholodniuk, Sophie Frech, Shaohua Zhu, Kim Purkhauser, Katharina Lipp, Franziska Werner, Vy Nguyen, Johannes Griss, Wolfgang Bauer, Ana Soler Cardona, Benedikt Weber, Wolfgang Weninger, Bernhard Gesslbauer, Clement Staud, Jakob Nedomansky, Christine Radtke, Stephan N. Wagner, Peter Petzelbauer, Maria Kasper, Beate M. Lichtenberger   +25 more
doaj   +1 more source