Results 11 to 20 of about 459,427 (295)

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]

, 2015
Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Bruder-Nascimento, Thiago, Cau, Stefany B.A., Fais, Rafael S., Lopes, Rheure A.M., Mestriner, Fabiola L.A.C., Silva, Marcondes A.B., Tostes, Rita C., Touyz, Rhian M.   +7 more
core   +7 more sources

Cross-Talk of NADPH Oxidases and Inflammation in Obesity

Antioxidants, 2023
Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity.
Henning Morawietz, Heike Brendel, Patrick Diaba-Nuhoho, Rusan Catar, Nikolaos Perakakis, Christian Wolfrum, Stefan R. Bornstein   +6 more
doaj   +1 more source

Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus. [PDF]

, 2017
To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM), 80 male Sprague-Dawley rats were fed with a high-sugar-high-fat diet to build a T2DM model.
Han, Xue, Liu, Huirong, Liu, Xin, Lv, Tingting, Ma, Lu, Ma, Xin-Liang, Sun, Qi, Wang, Ke, Wang, Wen, Wu, Ye, Xu, Wenli, Zhang, Suli   +11 more
core   +2 more sources

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]

, 2014
UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M, Gelli, Angie, Jamklang, Mantana, Na Pombejra, Sarisa, Tham, Rick, Thompson, George R, Uhrig, John P, Vu, Kiem   +7 more
core   +2 more sources

ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Vascular endothelial cell (EC) alignment in the direction of flow is an adaptive response that protects against aortic diseases, such as atherosclerosis. The Rho GTPases are known to regulate this alignment.
Angelina J. Lay, Paul R. Coleman, Ann Formaz‐Preston, Ka Ka Ting, Ben Roediger, Wolfgang Weninger, Martin A. Schwartz, Mathew A. Vadas, Jennifer R. Gamble   +8 more
doaj   +1 more source

“Endothelium-Out” and “Endothelium-In” Descemet Membrane Endothelial Keratoplasty (DMEK) Graft Insertion Techniques: A Systematic Review With Meta-Analysis

Frontiers in Medicine, 2022
BackgroundWe evaluated the visual outcomes and complications of “endothelium-out” and “endothelium-in” Descemet membrane endothelial keratoplasty (DMEK) graft insertion techniques.Materials and MethodsElectronic searches were conducted in CENTRAL ...
Hon Shing Ong, Hon Shing Ong, Hon Shing Ong, Hla M. Htoon, Hla M. Htoon, Marcus Ang, Marcus Ang, Marcus Ang, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta, Jodhbir S. Mehta   +11 more
doaj   +1 more source

Hemogenic Endothelium

Blood, 2010
Abstract Abstract SCI-44 Hematopoietic stem cells (HSCs) develop from endothelium in the midgestation mouse conceptus, starting at 10.5 days post coitus, through the formation of intra-aortic clusters. Studies in mouse, zebrafish, chick, and frog embryos established that Runx1 (AML1) is the earliest specific marker of the ...
Speck, N, Tober, J, Chen, M, De Bruijn, M, Chan, M   +4 more
openaire   +2 more sources

The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b

Molecular Therapy: Nucleic Acids, 2016
The regulation of function of endothelial cell–cell junctions is fundamental in sustaining vascular integrity. The polycistronic microRNA (miR) complexes containing miR-23a-27a-24-2, and 23b-27b-24-1 are predicted to target the majority of major ...
Jia Li, Yang Zhao, Ying Lu, William Ritchie, Georges Grau, Mathew A Vadas, Jennifer R Gamble   +6 more
doaj   +1 more source

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Goetz, Alwin Eduard, Massberg, S., Ney, L.   +3 more
core   +1 more source