Results 61 to 70 of about 313,061 (314)

Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries

Journal of Pharmacological Sciences, 2010
We compared mechanical responses to uridine-5′triphosphate (UTP) and 2-(methylthio)adenosine-5′diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced
Ayman Geddawy, Takashi Shimosato, Masashi Tawa, Takeshi Imamura, Tomio Okamura   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Proteomic profiling links complement activation to thrombosis in JAK2V617F myeloproliferative neoplasms

Translational Oncology
Background: Myeloproliferative neoplasms (MPNs) are associated with a high risk of thrombotic complications, particularly splanchnic vein thrombosis (SVT).
Blanca De Moner, Julia Martinez-Sanchez, Silvia Escribano-Serrat, Alex Ramos, Ana Belén Moreno-Castaño, Eduardo Arellano-Rodrigo, Ginés Escolar, Enric Carreras, Alberto Álvarez-Larrán, Maribel Diaz-Ricart   +9 more
doaj   +1 more source

Embryonic Stem Cell-like Population within Venous Malformation Expresses the Renin–Angiotensin System

Plastic and Reconstructive Surgery, Global Open, 2019
Background:. We have recently demonstrated the presence of a NANOG+/pSTAT3+/OCT4+/SOX2+/SALL4+/CD44+ embryonic stem cell (ESC)-like subpopulation localized to the endothelium and a NANOG+/pSTAT3+/SOX2+/CD44+ subpopulation outside of the endothelium ...
Elysia M.S. Tan, MBChB, Helen D. Brasch, MBChB, FRCPA, Paul F. Davis, PhD, Tinte Itinteang, MBBS, PhD, Swee T. Tan, ONZM, MBBS, PhD, FRACS   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II

Antioxidants
Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism ...
Michael Adu-Gyamfi, Claudia Goettsch, Julian Kamhieh-Milz, Lei Chen, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor Müller, Thomas Walther, Muhammad Imtiaz Ashraf, Henning Morawietz, Janusz Witowski, Rusan Catar   +12 more
doaj   +1 more source

Endothelium in Diseased States [PDF]

BioMed Research International, 2014
Endothelium is the endocrine organ essential for maintenance of homeostasis in the entire body. Endothelium operates by a broad spectrum of signaling molecules controlling the contractile state of vascular smooth muscles and cardiomyocytes; long distance intercellular synchronization within the vascular wall; adhesive, coagulant, and rheological ...
Iveta Bernatova, Ramaroson Andriantsitohaina, Silvia M. Arribas, Vladimir V. Matchkov   +3 more
openaire   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Journal of Aging Research, 2012
Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically ...
Hao Qian, Na Luo, Yuling Chi
doaj   +1 more source

Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function

, 2002
An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. We investigated whether carriage of the polymorphism was associated with functional changes in the endothelium, and how genotype ...
Jeerooburkhan, N., Muller, D.P.R., Mullen, M.J., Deanfield, J.E., Muller, DP, Deanfield, JE, Humphries, SE, Kattenhorn, M., Cole, T.J., Lucas, A, Humphries, S.E., Leeson, Christopher, Kattenhorn, M, Hingorani, AD, Jeerooburkhan, N, Hingorani, S.D., Leeson, CP, Mullen, MJ, Leeson, C.P.M., Cole, TJ, Lucas, A.   +20 more
core   +1 more source