Marine Drugs, 2014 An important problem of treating patients with endotoxemia is to find drugs to reduce the negative effects of endotoxin on the organism. We tested fucoidan (sulfated polysaccharide) from the brown alga Fucus evanescens as a potential drug in a mouse ...
Tatyana A. Kuznetsova +3 more
doaj +1 more source
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz +37 more
core +1 more source
Augmenting autophagy to treat acute kidney injury during endotoxemia in mice. [PDF]
PLoS ONE, 2013 To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic ...
Gina M Howell +8 more
doaj +1 more source
Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]
, 2016 The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann +3 more
core +3 more sources
Attenuation of Ventilation-Induced Endoplasmic Reticulum Stress Associated with Lung Injury Through Phosphoinositide 3-Kinase-Gamma in a Murine Endotoxemia Model. [PDF]
Int J Mol SciLi LF +6 more
europepmc +2 more sources
The clinical significance of the arterial ketone body ratio as an early indicator of graft viabilityin human liver transplantation [PDF]
, 1991 Arterial ketone body ratio (AKBR) was measured sequentially in 84 liver transplantations (OLTx). These transplantation procedures were classified into 3 groups with respect to graft survival and patient condition at the end of the first month (Group A ...
Asonuma, K +8 more
core +1 more source
Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia
Respiratory Research, 2018 Background ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion ...
Maurizio Turzo +4 more
doaj +1 more source
Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]
, 2014 Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core +1 more source
TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis
Molecular Medicine, 2018 Background Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis.
Yiting Tang +9 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2022 Aim. To study the relationship between the abundance of the genera in the gut microbiota (GM) and levels of serum biomarkers of chronic systemic inflammation and endotoxemia in patients with HFpEF.Material and methods.
A. N. Kaburova +10 more
doaj +1 more source