Results 41 to 50 of about 62,922 (266)

Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Frontiers in Immunology, 2018
Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature.
Sarah McKenna, Taylor Burey, Jeryl Sandoval, Leanna Nguyen, Odalis Castro, Suma Gudipati, Jazmin Gonzalez, Karim C. El Kasmi, Clyde J. Wright   +8 more
doaj   +1 more source

Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice

Frontiers in Medicine, 2021
Endotoxemia induced in vivo in mice by intraperitoneal injection of lipopolysaccharide (LPS) leads to (neuro)inflammation and sepsis. Also the homeostasis of mineral elements can be altered through mechanisms that still are poorly understood.
Rosa Grigoryan, Marta Costas-Rodríguez, Elien Van Wonterghem, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Frank Vanhaecke   +5 more
doaj   +1 more source

Glycocalyx in Endotoxemia and Sepsis [PDF]

The American Journal of Pathology, 2020
Along with the recognition of a crucial role played by endothelial dysfunction secondarily igniting cardiovascular, pulmonary, and renal complications, investigational focus has extended toward endothelial glycocalyx. This delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production ...
Michael S, Goligorsky, Dong, Sun
openaire   +2 more sources

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. [PDF]

, 2016
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed.
Cai, Linbi, Chen, Zishuo, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Lai, Yuchen, Liu, Zhenqui, Lugea, Aurelia, Luo, Mei, Nie, Yuanyang, Pandol, Stephen J, Su, Danmei, Sun, Qun, Tsukamoto, Hidekazu, Wu, Guihui, Wu, Pengfei, Xiao, Zhixiong, Zhang, Li, Zheng, Sujun, Zhu, Airu   +19 more
core   +2 more sources

Cognotoxemia: endotoxemia and gender predict changes in working memory performance in healthy adults

Frontiers in Neuroscience
IntroductionExamining the contribution of peripheral systems to cognitive function under healthy circumstances may improve our understanding of the systems that confer risk or resilience in diseased states.
Sally C. McDonnell, Jennifer E. Graham-Engeland, Jennifer E. Graham-Engeland, Martin J. Sliwinski, Martin J. Sliwinski, Christopher G. Engeland, Christopher G. Engeland, Christopher G. Engeland, Erik L. Knight   +8 more
doaj   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +2 more sources

Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2

Frontiers in Pharmacology, 2023
Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism and inflammation in critical illness, while autophagic degradation is a recently revealed mechanism that counter-regulates PKM2. Accumulating evidence suggests that
Shuang Zhao, Shuang Zhao, Yili Sun, Xicheng Wu, Yongqiang Yang, Kerui Fan, Kai Hu, Yasha Qin, Kexin Li, Ling Lin, Kun Chen, Yuhua Ma, Min Zhu, Gang Liu, Gang Liu, Li Zhang   +15 more
doaj   +1 more source

Endotoxemia after major vascular operations [PDF]

Journal of Vascular Surgery, 1993
Endotoxemia has been associated with syndromes such as adult respiratory distress syndrome and multiple organ failure. Translocation of endotoxins from the gut has been demonstrated to occur experimentally in animals after splanchnic ischemia.We investigated endotoxemia in 11 patients with hemorrhagic shock caused by a ruptured abdominal aortic ...
R M, Roumen, J T, Frieling, H W, van Tits, J A, van der Vliet, R J, Goris   +4 more
openaire   +2 more sources

Blood Storage Conditions Affect Hematological Analysis in Samples From Healthy Donkeys and Donkeys With Experimentally-Induced Endotoxemia

Frontiers in Veterinary Science, 2020
Preanalytical factors such as storage time and temperature are proved to induce marked artifactual changes in hematological parameters in horses, small animals and humans.
Alejandro Perez-Ecija, Antonio Buzon-Cuevas, Raul Aguilera-Aguilera, Carlos A. Gonzalez-De Cara, Francisco J. Mendoza   +4 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source